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TLR10 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS540461

Affinity Purified Toll-like receptor 10 AntibodyParticipates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). More details

$480 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TLR10, Polyclonal Antibody
Full Product Name
TLR10 Antibody
Product Gene Name
Product Synonym Names
CD 290; CD 290 antigen; TLR10; Toll like receptor 10; UNQ315/PRO358 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Chimpanzee, Human, Monkey, Pig, Rat
Form/Format
Affinity Purified
Concentration
0.55-0.67 ug/ul in antibody stabilization buffer (lot specific)
Preparation and Storage
-20 degree C for long term storage
Molecular Weight
94,564 Da
OMIM
606270
3D Structure
ModBase 3D Structure for Q9BXR5
Immunogen
Synthetic peptide taken within amino acid region 380-430 on human TLR10 protein.
Immunoglobulin
IgG
Expression
Highly expressed in spleen, lymph node, thymus, tonsil and at lower levels in lung. Highly expressed in promyelocytic HL-60 cells and in B-cell lines.
Molecular Function
Receptor, transmembrane signaling receptor activity
Structure
Binds MYD88 via their respective TIR domains (By similarity). Homodimer (Potential).
Subcellular Location
Membrane; Single-pass type I membrane protein
Applications Tested/Suitable for anti-TLR10 antibody
ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-TLR10 antibody
ELISA: 1:20,000
Immunocytochemistry: 1:100
Immunofluorescence: 1:100
Immunohistochemistry: 1:100
Immunoprecipitation: 1:200
Western Blot: 1:500

Western Blot (WB) of anti-TLR10 antibody

Rabbit Anti-TLR10 Polyclonal Antibody – Cat# MBS540461

Immunohistochemistry (IHC) of anti-TLR10 antibody

Rabbit Anti-TLR10 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS540461

Immunohistochemistry (IHC) of anti-TLR10 antibody

Rabbit Anti-TLR10 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS540461

Other Notes

Small volumes of anti-TLR10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TLR10 purchase

MBS540461 is an antibody targeting TLR10. Also known as TLR10 Antibody. Reactive in Chimpanzee, Human, Monkey, Pig, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TLR10. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
TLR10
NCBI Official Synonym Full Names
toll like receptor 10
NCBI Official Symbol
TLR10
NCBI Official Synonym Symbols
CD290
UniProt Protein Name
Toll-like receptor 10
UniProt Synonym Protein Names
CD_antigen: CD290
Protein Family
UniProt Gene Name
TLR10
UniProt Entry Name
TLR10_HUMAN
NCBI Protein Information
toll-like receptor 10

NCBI Summary for TLR10

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
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UniProt Comments for TLR10

TLR10: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Belongs to the Toll-like receptor family.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 4p14

Cellular Component: integral to plasma membrane; membrane; plasma membrane

Molecular Function: transmembrane receptor activity

Biological Process: immune response; inflammatory response; innate immune response; MyD88-dependent toll-like receptor signaling pathway; positive regulation of inflammatory response; regulation of cytokine secretion; toll-like receptor 10 signaling pathway; toll-like receptor signaling pathway
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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