SFRP2 Antibody – Rabbit Polyclonal

This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008]

SFRP2: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis. Belongs to the secreted frizzled-related protein (sFRP) family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q31.3

Cellular Component: extracellular matrix; extracellular space; integral to membrane

Molecular Function: fibronectin binding; G-protein coupled receptor activity; integrin binding; receptor agonist activity; Wnt receptor activity; Wnt-protein binding

Biological Process: cell-cell signaling; cellular response to extracellular stimulus; chondrocyte development; collagen fibril organization; convergent extension involved in axis elongation; digestive tract morphogenesis; embryonic digit morphogenesis; G-protein coupled receptor protein signaling pathway; male gonad development; negative regulation of BMP signaling pathway; negative regulation of caspase activity; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of JNK activity; negative regulation of mesodermal cell fate specification; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of transcription, DNA-dependent; negative regulation of Wnt receptor signaling pathway; patterning of blood vessels; positive regulation of angiogenesis; positive regulation of apoptosis; positive regulation of cell adhesion mediated by integrin; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of fat cell differentiation; positive regulation of osteoblast differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; response to drug; response to nutrient