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TMEM16A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS540571

Affinity Purified Transmembrane protein 16A Antibody C-epitopeCalcium-activated chloride channel (CaCC) which plays an important role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial… More details

$480 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TMEM16A, Polyclonal Antibody
Full Product Name
TMEM16A Antibody
Product Gene Name
anti-TMEM16A antibody
Product Synonym Names
ANO 1; Anoctamin 1; Anoctamin 1 calcium activated chloride channel; Ca2+ activated Cl- channel; Discovered on gastrointestinal stromal tumors protein 1; DOG 1; Membrane protein; Oral cancer overexpressed protein 2; ORAOV 2; TAOS2; Transmembrane protein 16A; Tumor-amplified and overexpressed sequence 2 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Affinity Purified
Concentration
0.50 ug/ul in antibody stabilization buffer (lot specific)
Preparation and Storage
-20 degree C for long term storage
Matching Pairs
Antibody: TMEM16A (MBS540571)
Positive Control: TMEM16A (MBS543330)
Molecular Weight
74,369 Da
OMIM
610108
3D Structure
ModBase 3D Structure for Q5XXA6
Immunogen
Synthetic peptide taken within amino acid region 900-950 on human Transmembrane protein 16A.
Expression
Highly expressed in pulmonary bronchiole epithelial cells, pancreatic and submandibular gland acinar cells, kidney proximal tubule, all retinal cell layers, most sensory cells of dorsal root ganglia, Leydig cells and spermatocytes (at protein level). Expressed at high levels in the thyroid gland and gastrointestinal muscles.
Determinant
C-epitope
Molecular Function
Chloride channel, Developmental protein, Ion channel
Structure
Homodimer. Interacts with CFTR (By similarity).
Subcellular Location
Cell membrane; Multi-pass membrane protein, Cytoplasm

Product Categories/Family for anti-TMEM16A antibody

Primary Antibodies; Cancer Research; Tumor Associated; TMEM16A Antibody
Applications Tested/Suitable for anti-TMEM16A antibody
ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-TMEM16A antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunoprecipitation: 1:200
Western Blot: 1:500

Western Blot (WB) of anti-TMEM16A antibody

Rabbit Anti-TMEM16A Polyclonal Antibody – Cat# MBS540571

Other Notes

Small volumes of anti-TMEM16A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TMEM16A purchase

MBS540571 is an antibody targeting TMEM16A. Also known as TMEM16A Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TMEM16A. It may not necessarily be applicable to this product.

NCBI GI #
74708278
NCBI GeneID
55107
NCBI Accession #
Q5XXA6.1
UniProt Primary Accession #
Q5XXA6
UniProt Secondary Accession #
Q8IYY8; Q8N7V3; A8KAM3
UniProt Related Accession #
Q5XXA6
NCBI Official Full Name
Anoctamin-1
NCBI Official Synonym Full Names
anoctamin 1
NCBI Official Symbol
ANO1
NCBI Official Synonym Symbols
DOG1; TAOS2; ORAOV2; TMEM16A
UniProt Protein Name
Anoctamin-1
UniProt Synonym Protein Names
Discovered on gastrointestinal stromal tumors protein 1; Oral cancer overexpressed protein 2; Transmembrane protein 16A; Tumor-amplified and overexpressed sequence 2
UniProt Gene Name
ANO1
UniProt Synonym Gene Names
DOG1; ORAOV2; TAOS2; TMEM16A
UniProt Entry Name
ANO1_HUMAN
NCBI Protein Information
anoctamin-1

UniProt Comments for TMEM16A

ANO1: Acts as a calcium-activated chloride channel. Required for normal tracheal development. Belongs to the anoctamin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter, ion channel; Transporter

Chromosomal Location of Human Ortholog: 11q13.3

Cellular Component: apical plasma membrane; cytoplasm; plasma membrane

Molecular Function: calcium activated cation channel activity; chloride channel activity; intracellular calcium activated chloride channel activity; iodide transmembrane transporter activity; protein binding; protein dimerization activity; voltage-gated chloride channel activity

Biological Process: cation transport; chloride transport; detection of temperature stimulus involved in sensory perception of pain; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); iodide transport; multicellular organismal development
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Research Articles on TMEM16A

1. Anoctamin and pendrin are two plausible candidates as mediators of apical iodide efflux--{review}

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TMEM16A antibody

 Products by Pathway  Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Stimuli-sensing Channels Pathway antibodies  Stimuli-sensing Channels Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-TMEM16A antibody

 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >46 publications with TMEM16A and Fibrosis
 Lung Diseases Antibodies  >21 publications with TMEM16A and Lung Diseases
 Adenocarcinoma Antibodies  >12 publications with TMEM16A and Adenocarcinoma
 Inflammation Antibodies  >10 publications with TMEM16A and Inflammation
 Disease Models, Animal Antibodies  >9 publications with TMEM16A and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >9 publications with TMEM16A and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >8 publications with TMEM16A and Breast Neoplasms
 Kidney Diseases Antibodies  >6 publications with TMEM16A and Kidney Diseases
 Uterine Neoplasms Antibodies  >5 publications with TMEM16A and Uterine Neoplasms
 Neoplasm Invasiveness Antibodies  >5 publications with TMEM16A and Neoplasm Invasiveness

Organs/Tissues associated with anti-TMEM16A antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >93 publications with TMEM16A and Muscle
 Intestine Antibodies  >34 publications with TMEM16A and Intestine
 Vascular Antibodies  >29 publications with TMEM16A and Vascular
 Stomach Antibodies  >23 publications with TMEM16A and Stomach
 Lung Antibodies  >21 publications with TMEM16A and Lung
 Brain Antibodies  >17 publications with TMEM16A and Brain
 Kidney Antibodies  >17 publications with TMEM16A and Kidney
 Salivary Gland Antibodies  >16 publications with TMEM16A and Salivary Gland
 Mouth Antibodies  >12 publications with TMEM16A and Mouth
 Eye Antibodies  >11 publications with TMEM16A and Eye
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