Rabbit Anti-TICAM2 Polyclonal Antibody – Cat# MBS540667

TICAM2 Antibody – Rabbit Polyclonal

Name: TICAM2 Antibody; Polyclonal; Rabbit; Human/Pig-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS540667
Price: 480 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS540667

Affinity Purified TIRAP3b long form AntibodyFunctions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to… More details

$480 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TICAM2, Polyclonal Antibody

Full Product Name

TICAM2 Antibody Affinity Purified

Product Gene Name

anti-TICAM2 antibody

Product Synonym Names

Putative NF-kappa-B-activating protein 502; TICAM2; TIR containing adapter molecule 2; TIR domain containing adaptor protein; TIR domain-containing adapter molecule 2; TIRAP3; TIRP; Toll-like receptor adaptor protein 3; Toll/interleukin-1 receptor domain-containing protein; TRAM; TRIF-related adapter molecule antibody

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Cat, Human, Monkey, Pig

Form/Format

Affinity Purified

Concentration

0.60-0.65 ug/ul in antibody stabilization buffer (lot specific)

Preparation and Storage

-20 degree C for long term storage

Matching Pairs

Antibody: TICAM2 (MBS540667)
Positive Control: TICAM2 (MBS543313)

Antibody/Peptide Pairs

TICAM2 peptide (MBS544569) is used for blocking the activity of TICAM2 antibody (MBS540667)

Molecular Weight

46,173 Da

OMIM

608321

3D Structure

ModBase 3D Structure for Q86XR7

Immunogen

Synthetic peptide taken within amino acid region 140-170 on human TIRAP3b long form protein.

Expression

Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at lower levels than isoform 1).

Molecular Function

Phospholipid binding, signal transducer activity

Structure

Homodimer. Interacts with TLR4, TICAM1, IRF3 and IRF7 in response to LPS. Interacts with IL1R1, IL1RAP, IRAK2, IRAK3 and TRAF6. Interacts with protein kinase-inactive mutants of IRAK1 and IRAK4. Isoform 1 interacts with isoform 2; the interaction occurs i

Subcellular Location

Isoform 1: Cytoplasm, Golgi apparatus, Cell membrane, Endoplasmic Reticulum, Early endosome membrane, Late endosome membrane. Isoform 2: Endoplasmic Reticulum, Early endosome membrane, Late endosome membrane

Product Categories/Family for anti-TICAM2 antibody

Primary Antibodies; TICAM2 Antibody

Applications Tested/Suitable for anti-TICAM2 antibody

ELISA (EIA), Western Blot (WB)

Application Notes for anti-TICAM2 antibody

Dot Blot: 1:10,000
ELISA: 1:10,000
Western Blot: 1:250

Other Notes

Small volumes of anti-TICAM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TICAM2 purchase

MBS540667 is an antibody targeting TICAM2. Also known as TICAM2 Antibody Affinity Purified. Reactive in Cat, Human, Monkey, Pig. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TICAM2. It may not necessarily be applicable to this product.

NCBI GI #

37677661

NCBI GeneID

100302736

NCBI Accession #

AAQ97430.1

UniProt Primary Accession #

Q86XR7

UniProt Secondary Accession #

Q6JUT2; B3Y698

NCBI Official Full Name

TIRAP3b long form

NCBI Official Synonym Full Names

TMED7-TICAM2 readthrough

NCBI Official Symbol

TMED7-TICAM2

UniProt Protein Name

TIR domain-containing adapter molecule 2

UniProt Synonym Protein Names

Putative NF-kappa-B-activating protein 502; TRIF-related adapter molecule; Toll-like receptor adaptor protein 3; Toll/interleukin-1 receptor domain-containing protein; MyD88-4

Protein Family

TIR domain-containing adapter molecule

UniProt Gene Name

TICAM2

UniProt Synonym Gene Names

TIRAP3; TIRP; TRAM; TICAM-2; MyD88-4

UniProt Entry Name

TCAM2_HUMAN

NCBI Protein Information

TRAM adaptor with GOLD domain

NCBI Summary for TICAM2

This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010]

UniProt Comments for TICAM2

Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TICAM2 antibody

Products by Pathway	Pathway Diagram
IL1-mediated Signaling Events Pathway antibodies	IL1-mediated Signaling Events Pathway Diagram
Toll-like Receptor Signaling Pathway antibodies	Toll-like Receptor Signaling Pathway Diagram

Diseases associated with anti-TICAM2 antibody

Disease Name	Pubmed Publications
Cell Transformation, Neoplastic Antibodies	>1 publications with TICAM2 and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-TICAM2 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1 publications with TICAM2 and Blood