Phospho-Eph Receptor A4 (EPHA4) Antibody – Rabbit Polyclonal

EphA4: a tyrosine kinase receptor of the Eph family. Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A4 and -A5. Binds more poorly to ephrin-A2 and -A3. May play a role in hindbrain pattern formation. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels.

Protein type: Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); Kinase, protein; EC 2.7.10.1; TK group; Eph family

Cellular Component: axon; cell junction; cell projection; cell surface; cytoplasm; dendrite; dendritic spine; early endosome membrane; endoplasmic reticulum; endosome; filopodium; Golgi apparatus; integral to membrane; integral to plasma membrane; membrane; mitochondrial outer membrane; nerve terminal; neuromuscular junction; perikaryon; plasma membrane; postsynaptic density; postsynaptic membrane; synapse

Molecular Function: ATP binding; ephrin receptor activity; ephrin receptor binding; GPI-linked ephrin receptor activity; identical protein binding; kinase activity; nucleotide binding; PH domain binding; protein binding; protein kinase activity; protein-tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity; transmembrane-ephrin receptor activity

Biological Process: adult walking behavior; axon guidance; cell adhesion; corticospinal tract morphogenesis; ephrin receptor signaling pathway; glial cell migration; motor axon guidance; multicellular organismal development; negative regulation of axon regeneration; nervous system development; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of dendrite morphogenesis; positive regulation of JNK activity; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of astrocyte differentiation; regulation of axonogenesis; regulation of GTPase activity; transmembrane receptor protein tyrosine kinase signaling pathway