KIF14 Antibody – Rabbit Polyclonal

This gene encodes a member of the kinesin-3 superfamily of microtubule motor proteins. These proteins are involved in numerous processes including vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis. In human HeLa-S3 and 293T cells, this protein is localized to the cytoplasm during interphase, to the spindle poles and spindle microtubules during mitosis, and to the midbody during cytokinesis. An internal motor domain displays microtubule-dependent ATPase activity, consistent with its function as a microtubule motor protein. Knockdown of this gene results in failed cytokinesis with endoreplication, which results in multinucleated cells. This gene has been identified as a likely oncogene in breast, lung and ovarian cancers, as well as retinoblastomas and gliomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]

KIF14: Plays an essential role in cytokinesis. Belongs to the kinesin-like protein family.

Protein type: Microtubule-binding; Motor

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: cytosol; kinesin complex; membrane; microtubule; midbody; nucleus; plasma membrane; spindle midzone

Molecular Function: ATP binding; ATPase activity; microtubule binding; microtubule motor activity; PDZ domain binding; plus-end-directed microtubule motor activity; protein binding; protein kinase binding; tubulin binding

Biological Process: activation of protein kinase activity; cell division; cell proliferation in forebrain; cerebellar cortex development; cerebellar granular layer structural organization; cerebellar Purkinje cell layer structural organization; cerebral cortex development; cytoskeleton-dependent intracellular transport; establishment of protein localization; hippocampus development; microtubule depolymerization; microtubule-based movement; mitotic metaphase plate congression; negative regulation of apoptosis; negative regulation of integrin activation; negative regulation of neuron apoptosis; olfactory bulb development; positive regulation of cell proliferation; positive regulation of cytokinesis; proteasomal ubiquitin-dependent protein catabolic process; regulation of cell adhesion; regulation of cell growth; regulation of cell migration; regulation of G2/M transition of mitotic cell cycle; regulation of myelination; regulation of neuron apoptosis; regulation of Rap protein signal transduction; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Disease: Meckel Syndrome 12