Rabbit Anti-TICRR Polyclonal Antibody – Cat# MBS540790

C15orf42 (TICRR) Antibody – Rabbit Polyclonal

Name: TICRR Antibody; Polyclonal; Rabbit; Human/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS540790
Price: 480 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS540790

Affinity Purified Treslin AntibodyRegulates triggering of DNA replication onto replication origins, required for transition from pre-replication complex to pre-initiation complex. Required to prevent mitotic entry after treatment with ionizing radiation. More details

$480 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

C15orf42 (TICRR), Polyclonal Antibody

Full Product Name

C15orf42 Antibody Affinity Purified

Product Gene Name

anti-TICRR antibody

Product Synonym Names

C15orf42; chromosome 15 open reading frame 42; replication-stimulating protein; SLD3; SLD3 homolog; SLD3, yeast, homolog of; TICRR; TopBP1-interacting checkpoint and replication regulator; Treslin antibody

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human, Rat

Form/Format

Affinity Purified

Concentration

0.55-0.75 ug/ul in antibody stabilization buffer (lot specific)

Preparation and Storage

-20 degree C for long term storage

Matching Pairs

Antibody: C15orf42 (MBS540790)
Positive Control: C15orf42 (MBS543357)

Antibody/Peptide Pairs

C15orf42 peptide (MBS544624) is used for blocking the activity of C15orf42 antibody (MBS540790)

Molecular Weight

210,786 Da

OMIM

613298

3D Structure

ModBase 3D Structure for Q7Z2Z1

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on human Treslin protein.

Molecular Function

Chromatin binding

Subcellular Location

Nucleus

Product Categories/Family for anti-TICRR antibody

Primary Antibodies; Epigenetics; DNA/RNA; C15orf42 Antibody

Applications Tested/Suitable for anti-TICRR antibody

ELISA (EIA), Western Blot (WB)

Application Notes for anti-TICRR antibody

Dot Blot: 1:10,000
ELISA: 1:10,000
Western Blot: 1:500

Other Notes

Small volumes of anti-TICRR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TICRR purchase

MBS540790 is an antibody targeting TICRR. Also known as C15orf42 Antibody Affinity Purified. Reactive in Human, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TICRR. It may not necessarily be applicable to this product.

NCBI GI #

118421085

NCBI GeneID

90381

NCBI Accession #

NP_689472.3

UniProt Primary Accession #

Q7Z2Z1

UniProt Secondary Accession #

Q8N4X8; Q8NCH6; Q9BU55; B2RE07; B3KVV9; D3IUT4

UniProt Related Accession #

Q7Z2Z1

GenBank Nucleotide #

NM_152259.3

NCBI Official Full Name

treslin isoform 2

NCBI Official Synonym Full Names

TOPBP1 interacting checkpoint and replication regulator

NCBI Official Symbol

TICRR

NCBI Official Synonym Symbols

SLD3; Treslin; C15orf42

UniProt Protein Name

Treslin

UniProt Synonym Protein Names

TopBP1-interacting checkpoint and replication regulator; TopBP1-interacting, replication-stimulating protein

Protein Family

Treslin

UniProt Gene Name

TICRR

UniProt Synonym Gene Names

C15orf42

UniProt Entry Name

TICRR_HUMAN

NCBI Protein Information

treslin

NCBI Summary for TICRR

Treslin is involved in the initiation of DNA replication (Kumagai et al., 2010 [PubMed 20116089]).[supplied by OMIM, Apr 2010]

UniProt Comments for TICRR

TICRR: Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre- initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation. Belongs to the treslin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; DNA replication

Chromosomal Location of Human Ortholog: 15q26.1

Cellular Component: nucleoplasm; nucleus

Molecular Function: chromatin binding; protein binding

Biological Process: cell cycle checkpoint; DNA repair; DNA replication; formation of translation preinitiation complex; mitotic cell cycle DNA replication checkpoint; regulation of DNA replication initiation; response to ionizing radiation

Research Articles on TICRR

1. identified a point mutation of Sld3 that is specifically defective for Mcm3 and Mcm5 interaction (sld3-m10), and also identified a point mutation of Sld3 that is specifically defective for single-stranded DNA interaction (sld3-m9)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-TICRR antibody

Disease Name	Pubmed Publications
Lung Diseases Antibodies	>1 publications with TICRR and Lung Diseases
Anoxia Antibodies	>1 publications with TICRR and Anoxia