DNA Pkcs (DCC) Antibody – Chicken Polyclonal

This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]

DCC: Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. Defects in DCC are the cause of mirror movements type 1 (MRMV1). A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities. Belongs to the immunoglobulin superfamily. DCC family.

Protein type: Receptor, misc.; Tumor suppressor; Membrane protein, integral; Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 18q21.3

Cellular Component: axon; cytosol; integral to membrane; plasma membrane

Molecular Function: netrin receptor activity; protein binding; transmembrane receptor activity

Biological Process: anterior/posterior axon guidance; apoptosis; axon guidance; axonogenesis; dorsal/ventral axon guidance; negative regulation of collateral sprouting; neuron migration; spinal cord ventral commissure morphogenesis

Disease: Colorectal Cancer; Esophageal Cancer; Mirror Movements 1