Aquaporin 2 (AQP2) Antibody – Rabbit Polyclonal

This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus. [provided by RefSeq, Oct 2008]

AQP2: Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Expressed in renal collecting tubules. Belongs to the MIP/aquaporin (TC 1.A.8) family.

Protein type: Channel, misc.; Transporter, aquaporin family; Membrane protein, integral; Transporter; Membrane protein, multi-pass

Cellular Component: apical plasma membrane; basolateral plasma membrane; clathrin-coated vesicle; cytoplasm; cytoplasmic vesicle; cytoplasmic vesicle membrane; early endosome; integral to plasma membrane; lysosome; membrane; plasma membrane; pore complex; protein complex; recycling endosome; rough endoplasmic reticulum; trans-Golgi network; transport vesicle

Molecular Function: actin binding; glycerol channel activity; glycerol transmembrane transporter activity; PDZ domain binding; porin activity; protein binding; water channel activity; water transporter activity

Biological Process: actin filament depolymerization; aging; apoptosis; cell volume homeostasis; cellular response to water deprivation; cellular water homeostasis; female pregnancy; glycerol transport; hyperosmotic response; positive regulation of calcium ion transport; renal water transport; response to calcium ion; response to glucagon stimulus; response to hormone stimulus; response to lipopolysaccharide; response to lithium ion; response to salt stress; response to starvation; response to water deprivation; transmembrane transport; water homeostasis; water transport