AXL Antibody – Rabbit Polyclonal

AXL: a receptor tyrosine kinase that may function as a signal transducer between specific cell types of mesodermal origin. Interacts with SKP1. Overexpression in tissue culture causes oncogenic transformation. Overexpressed in several cancers including thyroid, ovarian, gastric, ER+ breast cancer and acute myeloid leukemia, where it is associated with poor prognosis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; EC 2.7.10.1; Protein kinase, TK; Protein kinase, tyrosine (receptor); Oncoprotein; Kinase, protein; TK group; Axl family

Cellular Component: cell surface; extracellular space; integral to membrane; membrane; plasma membrane

Molecular Function: ATP binding; kinase activity; myosin heavy chain binding; nucleotide binding; phosphatidylserine binding; phosphoinositide 3-kinase binding; protein heterodimerization activity; protein kinase activity; protein-tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity

Biological Process: apoptotic cell clearance; blood vessel remodeling; cell differentiation; cellular response to extracellular stimulus; entry of virus into host cell; enzyme linked receptor protein signaling pathway; erythrocyte homeostasis; forebrain cell migration; immune system process; inflammatory response; innate immune response; natural killer cell differentiation; negative regulation of apoptosis; negative regulation of interferon-gamma production; negative regulation of lymphocyte activation; negative regulation of neuron apoptosis; negative regulation of tumor necrosis factor production; neuron migration; ovulation cycle; peptidyl-tyrosine phosphorylation; phagocytosis; phosphorylation; platelet activation; positive regulation of cytokine and chemokine mediated signaling pathway; positive regulation of natural killer cell differentiation; positive regulation of pinocytosis; positive regulation of protein kinase B signaling cascade; protein amino acid phosphorylation; protein kinase B signaling cascade; secretion by cell; spermatogenesis; vagina development