BMP2 Antibody – Rabbit Polyclonal

This gene encodes a member of a family of secreted factors that participate in developmental signal transduction to stimulate SMAD transcriptional activators. The encoded protein is able to induce cartilage and bone formation. The propeptide is further cleaved into an active chain. [provided by RefSeq, Mar 2013]

BMP2: Induces cartilage and bone formation. Belongs to the TGF-beta family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Cellular Component: cell surface; cytoplasm; extracellular region; extracellular space; protein complex

Molecular Function: cytokine activity; growth factor activity; phosphatase activator activity; protein binding; protein domain specific binding; protein heterodimerization activity; protein homodimerization activity; receptor binding; retinol dehydrogenase activity; SMAD binding; transforming growth factor beta receptor binding

Biological Process: activation of MAPK activity; adrenocorticotropin hormone secreting cell differentiation; BMP signaling pathway; bone mineralization; cardiac cell differentiation; cardiac muscle cell differentiation; cardiac muscle morphogensis; cartilage development; cell differentiation; cell fate commitment; chondrocyte differentiation; embryonic development; embryonic heart tube anterior/posterior pattern formation; epithelial to mesenchymal transition; growth; heart development; in utero embryonic development; inner ear development; mesenchymal cell differentiation; multicellular organismal development; negative regulation of aldosterone biosynthetic process; negative regulation of calcium-independent cell-cell adhesion; negative regulation of cell cycle; negative regulation of cell proliferation; negative regulation of insulin-like growth factor receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; Notch signaling pathway; odontogenesis of dentine-containing teeth; organ morphogenesis; ossification; osteoblast differentiation; pericardium development; positive regulation of apoptosis; positive regulation of astrocyte differentiation; positive regulation of bone mineralization; positive regulation of cell differentiation; positive regulation of cell migration; positive regulation of endothelial cell proliferation; positive regulation of fat cell differentiation; positive regulation of MAPKKK cascade; positive regulation of neurogenesis; positive regulation of neuron differentiation; positive regulation of odontogenesis; positive regulation of ossification; positive regulation of osteoblast differentiation; positive regulation of osteoblast proliferation; positive regulation of protein amino acid phosphorylation; positive regulation of protein binding; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of Wnt receptor signaling pathway; protein amino acid phosphorylation; protein destabilization; proteoglycan metabolic process; regulation of apoptosis; regulation of MAPKKK cascade; regulation of odontogenesis of dentine-containing teeth; regulation of transcription, DNA-dependent; response to hypoxia; telencephalon development; telencephalon regionalization; thyroid stimulating hormone secreting cell differentiation; transforming growth factor beta receptor signaling pathway; ureteric bud branching