CDX2 Antibody – Rabbit Polyclonal

This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012]

CDX2: Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Belongs to the Caudal homeobox family.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 13q12.3

Cellular Component: condensed nuclear chromosome; nucleoplasm; nucleus; transcriptional repressor complex

Molecular Function: transcription corepressor activity; transcription factor activity

Biological Process: anterior/posterior axis specification; blood vessel development; cell differentiation; endosome to lysosome transport; establishment and/or maintenance of epithelial cell polarity; negative regulation of transcription from RNA polymerase II promoter; organ morphogenesis; positive regulation of cell differentiation; positive regulation of cell proliferation; positive regulation of transcription, DNA-dependent; regulation of somitogenesis; somatic stem cell maintenance; transcription from RNA polymerase II promoter; trophectodermal cell differentiation