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CXCR3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS541350

FITC-Conjugated IP10 Receptor AntibodyReceptor for C-X-C chemokines: CXCL9, CXCCl10 and CXCL11, mediates the proliferation, survival and angiogenic activity of mesangial cells via a heterotrimeric G-protein signalling pathway More details

$610 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CXCR3, Polyclonal Antibody
Full Product Name
CXCR3 Antibody FITC-Conjugated
Product Gene Name
anti-CXCR3 antibody
Product Synonym Names
C-X-C chemokine receptor type 3; CD 183; CD182; Chemokine CXC Motif Receptor 3; CKR L2; CKR-L2; CMKAR3; CXC-R3; G protein-coupled receptor 9; GPR9; Interferon-inducible protein 10 receptor; IP-10 receptor; Mig R; Mig receptor antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
FITC-Conjugated
Concentration
0.50-0.60 ug/ul in antibody stabilization buffer (lot specific)
Preparation and Storage
-20 degree C for long term storage
Antibody/Peptide Pairs
CXCR3 peptide (MBS543391) is used for blocking the activity of CXCR3 antibody (MBS541350)
Molecular Weight
40,935 Da
Immunogen
Synthetic peptide taken within amino acid region 20-70 on rat CXCR3 protein
Molecular Function
G-Protein coupled receptor, Transducer, chemokine receptor activity
Structure
Homomer, forms heteromers with ACKR4 by similarity
Subcellular Location
Cell membrane; Multipass membrane protein
Applications Tested/Suitable for anti-CXCR3 antibody
Confocal Microscopy (CM), ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), IMM, Western Blot (WB)
Application Notes for anti-CXCR3 antibody
Confocal Microscopy||1:200
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunocytochemistry: 1:200
Immunofluorescence: 1:200
Immunohistochemistry: 1:200
Immunoprecipitation: 1:250
Western Blot: 1:500

Other Notes

Small volumes of anti-CXCR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CXCR3 purchase

MBS541350 is an antibody targeting CXCR3. Also known as CXCR3 Antibody FITC-Conjugated. Reactive in Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CXCR3. It may not necessarily be applicable to this product.

NCBI GI #
16758152
NCBI GeneID
84475
NCBI Accession #
NP_445867.1
UniProt Related Accession #
Q9JII9
GenBank Nucleotide #
NM_053415.1
NCBI Official Full Name
C-X-C chemokine receptor type 3
NCBI Official Synonym Full Names
C-X-C motif chemokine receptor 3
NCBI Official Symbol
Cxcr3
NCBI Official Synonym Symbols
Gpr9
UniProt Protein Name
C-X-C chemokine receptor type 3
UniProt Synonym Protein Names
Interferon-inducible protein 10 receptor; IP-10 receptor; CD_antigen: CD183
Protein Family
C-X-C chemokine receptor
UniProt Gene Name
Cxcr3
UniProt Synonym Gene Names
CXC-R3; CXCR-3; IP-10 receptor
UniProt Entry Name
CXCR3_RAT
NCBI Protein Information
C-X-C chemokine receptor type 3

NCBI Summary for CXCR3

binds interferon-inducible protein-10 and induces intracellular calcium mobilization; increased expression occurs in response to focal stroke [RGD, Feb 2006]

UniProt Comments for CXCR3

CXCR3: Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC). Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR

Cellular Component: cell surface; external side of plasma membrane; integral to membrane; intracellular; plasma membrane

Molecular Function: C-X-C chemokine binding; C-X-C chemokine receptor activity; chemokine binding; receptor activity

Biological Process: angiogenesis; calcium-mediated signaling; cell surface receptor linked signal transduction; chemotaxis; elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; inflammatory response; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; positive regulation of angiogenesis; positive regulation of cAMP metabolic process; positive regulation of cell proliferation; positive regulation of chemotaxis; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of transcription from RNA polymerase II promoter; regulation of leukocyte migration
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Research Articles on CXCR3

1. Our results demonstrated that the activation of spinal chemokine receptor CXCR3 mediated bone cancer pain through Akt and ERK 1/2 kinase

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CXCR3 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
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