Dopamine Receptor D3 (DRD3) Antibody – Rabbit Polyclonal

DRD3: Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. Genetic variation in DRD3 is associated with essential tremor hereditary type 1 (ETM1). ETM1 is the most common movement disorder. The main feature is postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: apical part of cell; cell projection; endocytic vesicle; integral to plasma membrane; membrane; plasma membrane

Molecular Function: D1 dopamine receptor binding; dopamine binding; dopamine D1 receptor-like receptor activity; dopamine D2 receptor-like receptor activity; dopamine receptor activity; drug binding; protein binding; protein domain specific binding

Biological Process: acid secretion; arachidonic acid secretion; behavioral response to cocaine; cellular calcium ion homeostasis; circadian regulation of gene expression; dopamine receptor signaling pathway; dopamine receptor, adenylate cyclase activating pathway; dopamine receptor, adenylate cyclase inhibiting pathway; G-protein coupled receptor internalization; G-protein coupled receptor protein signaling pathway; locomotory behavior; musculoskeletal movement, spinal reflex action; negative regulation of adenylate cyclase activity; negative regulation of blood pressure; negative regulation of dopamine receptor signaling pathway; negative regulation of oligodendrocyte differentiation; negative regulation of protein kinase B signaling cascade; negative regulation of protein secretion; negative regulation of sodium:hydrogen antiporter activity; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell proliferation; positive regulation of cytokinesis; positive regulation of dopamine receptor signaling pathway; positive regulation of mitosis; positive regulation of transcription from RNA polymerase II promoter; prepulse inhibition; regulation of cAMP metabolic process; regulation of circadian sleep/wake cycle, sleep; regulation of dopamine secretion; regulation of lipid metabolic process; regulation of locomotion; regulation of multicellular organism growth; renin-angiotensin regulation of blood volume; response to amphetamine; response to cocaine; response to drug; response to ethanol; response to morphine; synaptic transmission, dopaminergic; visual learning