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EPAC1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS541509

BIOTIN-Conjugated Rap Guanine Nucleotide Exchange Factor 3 Antibody N-epitopeGuanine nucleotide exchange factor for RAP1A and RAP2A small GTPases that are activated by binding cAMP More details

$610 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
EPAC1, Polyclonal Antibody
Full Product Name
Epac1 Antibody BIOTIN-Conjugated
Product Gene Name
anti-EPAC1 antibody
Product Synonym Names
bcm910; CGEF 1; Epac 1; EPAC; Exchange protein directly activated by cAMP 1; MGC21410; RAP guanine nucleotide exchange factor; RAPGEF3 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Horse, Human, Mouse, Rat
Form/Format
BIOTIN-Conjugated
Concentration
0.59 ug/ul in antibody stabilization buffer (lot specific)
Preparation and Storage
-20 degree C for long term storage
Antibody/Peptide Pairs
EPAC1 peptide (MBS543636) is used for blocking the activity of EPAC1 antibody (MBS541509)
Molecular Weight
99,452 Da
OMIM
606057
3D Structure
ModBase 3D Structure for O95398
Immunogen
Synthetic peptide corresponding to amino acid region 9-26 of Epac1, peptide was covalently modified.
Synthetic peptide: PRSCSYQLLLEHQRPSCI
Expression
Widely expressed with highest levels in kidney, heart, thyroid and brain
Determinant
N-epitope
Molecular Function
cAMP-binding; Nucleotide-binding
Structure
Interacts with PDE3B
Subcellular Location
Endomembrane system
Applications Tested/Suitable for anti-EPAC1 antibody
Confocal Microscopy (CM), ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-EPAC1 antibody
Confocal Microscopy||1:200
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunocytochemistry: 1:200
Immunofluorescence: 1:200
Immunohistochemistry: 1:200
Western Blot: 1:500

Other Notes

Small volumes of anti-EPAC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EPAC1 purchase

MBS541509 is an antibody targeting EPAC1. Also known as Epac1 Antibody BIOTIN-Conjugated. Reactive in Horse, Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for EPAC1. It may not necessarily be applicable to this product.

NCBI GI #
4079649
NCBI GeneID
10411
NCBI Accession #
AAD12740.1
UniProt Primary Accession #
O95398
UniProt Secondary Accession #
O95634; Q8WVN0; A8K2G5; E7EQC8
UniProt Related Accession #
O95398
NCBI Official Full Name
cAMP-regulated guanine nucleotide exchange factor I
NCBI Official Synonym Full Names
Rap guanine nucleotide exchange factor 3
NCBI Official Symbol
RAPGEF3
NCBI Official Synonym Symbols
EPAC; EPAC1; bcm910; HSU79275; CAMP-GEFI
UniProt Protein Name
Rap guanine nucleotide exchange factor 3
UniProt Synonym Protein Names
Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; EPAC 1; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP; cAMP-regulated guanine nucleotide exchange factor I; cAMP-GEFI
UniProt Gene Name
RAPGEF3
UniProt Synonym Gene Names
CGEF1; EPAC; EPAC1; EPAC 1; cAMP-GEFI
UniProt Entry Name
RPGF3_HUMAN
NCBI Protein Information
rap guanine nucleotide exchange factor 3

UniProt Comments for EPAC1

Epac1: Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, misc.

Chromosomal Location of Human Ortholog: 12q13.1

Cellular Component: apical part of cell; basal plasma membrane; brush border membrane; cell soma; cortical actin cytoskeleton; endomembrane system; filopodium; growth cone; lamellipodium; membrane; microvillus; perinuclear region of cytoplasm; plasma membrane

Molecular Function: cAMP binding; guanyl-nucleotide exchange factor activity; protein binding; protein domain specific binding; Rap guanyl-nucleotide exchange factor activity

Biological Process: angiogenesis; brain development; cAMP-mediated signaling; cell proliferation; negative regulation of collagen biosynthetic process; positive regulation of angiogenesis; positive regulation of cAMP catabolic process; positive regulation of cell size; positive regulation of GTPase activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein export from nucleus; positive regulation of smooth muscle cell migration; positive regulation of stress fiber formation; positive regulation of syncytium formation by plasma membrane fusion; positive regulation of transcription from RNA polymerase II promoter; Rap protein signal transduction; regulation of insulin secretion; response to nicotine; signal transduction; spinal cord development
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Research Articles on EPAC1

1. The cAMP exerted divergent effects on proliferation and promoted cell adhesion of different neuroendocrine cell types, these effects being mediated by both Epac and PKA and involving the same effector GTPase Rap1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-EPAC1 antibody

 Reference Product  PubMed Publications
 RAP1B antibody  >7 publications with EPAC1 and RAP1B
 RAP1A antibody  >7 publications with EPAC1 and RAP1A
 PDE3B antibody  >4 publications with EPAC1 and PDE3B
 RAP1GAP antibody  >3 publications with EPAC1 and RAP1GAP
 PDE4A antibody  >1 publications with EPAC1 and PDE4A
 ABCC8 antibody  >1 publications with EPAC1 and ABCC8

Pathways associated with anti-EPAC1 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Glucagon-like Peptide-1 (GLP1) Regulates Insulin Secretion Pathway antibodies  Glucagon-like Peptide-1 (GLP1) Regulates Insulin Secretion Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Integration Of Energy Metabolism Pathway antibodies  Integration Of Energy Metabolism Pathway Diagram
 Integrin AlphaIIb Beta3 Signaling Pathway antibodies  Integrin AlphaIIb Beta3 Signaling Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram

Diseases associated with anti-EPAC1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >18 publications with EPAC1 and Inflammation
 Cardiovascular Diseases Antibodies  >15 publications with EPAC1 and Cardiovascular Diseases
 Hypertrophy Antibodies  >14 publications with EPAC1 and Hypertrophy
 Heart Diseases Antibodies  >13 publications with EPAC1 and Heart Diseases
 Vascular Diseases Antibodies  >11 publications with EPAC1 and Vascular Diseases
 Lung Diseases Antibodies  >8 publications with EPAC1 and Lung Diseases
 Heart Failure Antibodies  >7 publications with EPAC1 and Heart Failure
 Edema Antibodies  >5 publications with EPAC1 and Edema
 Fibrosis Antibodies  >5 publications with EPAC1 and Fibrosis
 Necrosis Antibodies  >5 publications with EPAC1 and Necrosis

Organs/Tissues associated with anti-EPAC1 antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >45 publications with EPAC1 and Vascular
 Blood Antibodies  >37 publications with EPAC1 and Blood
 Muscle Antibodies  >35 publications with EPAC1 and Muscle
 Heart Antibodies  >33 publications with EPAC1 and Heart
 Lung Antibodies  >25 publications with EPAC1 and Lung
 Pancreas Antibodies  >15 publications with EPAC1 and Pancreas
 Brain Antibodies  >15 publications with EPAC1 and Brain
 Kidney Antibodies  >9 publications with EPAC1 and Kidney
 Umbilical Cord Antibodies  >6 publications with EPAC1 and Umbilical Cord
 Prostate Antibodies  >6 publications with EPAC1 and Prostate
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