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FOXP3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS541629

Forkhead box protein 3 Antibody BIOTIN-ConjugatedTranscriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the… More details

$610 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FOXP3, Polyclonal Antibody
Full Product Name
FOXP3 Antibody BIOTIN
Product Gene Name
anti-FOXP3 antibody
Product Synonym Names
AIID; DIETER; Forkhead box P3; FOXP3delta7; Immune dysregulation polyendocrinopathy enteropathy X linked; IPEX; JM2; MGC141961; MGC141963; PIDX; SCURFIN; XPID antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Bovine, Cat, Human, Monkey, Mouse, Pig, Rat
Predicted: Pig, Cynomolgus monkey, Rhesus monkey, Deer
Form/Format
BIOTIN-Conjugated
Concentration
0.7 ug/ul in antibody stabilization buffer (lot specific)
Preparation and Storage
-20 degree C for long term storage
Matching Pairs
Antibody: FOXP3 (MBS541629)
Positive Control: FOXP3 (MBS542771)
Antibody/Peptide Pairs
FOXP3 peptide (MBS543700) is used for blocking the activity of FOXP3 antibody (MBS541629)
Molecular Weight
17,785 Da
3D Structure
ModBase 3D Structure for Q9H5F2
Immunogen
Synthetic peptide corresponding to amino acids 229-250 of Mouse Forkhead Box Protein 3 (winged helix transcription factor 3 protein). The peptide was post synthetically modified to achieve desired antigenicity before coupling to a carrier protein.
Sequence: AQCLLQREVVQSLEQQLELEKE
Immunoglobulin
IgG
Expression
Down-regulated in regulatory T-cells (Treg) during inflammation.
Molecular Function
Core promoter binding; Histone Acetyltransferase binding; Histone deacetylase binding; NFAT protein binding; NF-kappaB binding; Activator; Repressor
Structure
Homodimer. Interacts with IKZF3. Isoform 1 (via LXXLL motif), but not isoform 2, interacts with isoform 4 of RORA (via AF-2 motif). Interacts with STUB1, HSPA8 and HSPA1A/B. Interacts with PPP1CA, PPP1CB and PPP1CG. Interacts with KAT5 and HDAC7. Interacts with HDAC9 in the absence of T-cell stimulation. Interacts with USP7. Interacts with isoform 2 of ZFP90 and can form a complex with TRIM28 in the presence of isoform 2 of ZFP90. Interacts with RUNX1. Interacts with RORC. Interacts with RELA and NFATC2. Interacts with RUNX2, RUNX3 and IKZF4.
Subcellular Location
Nucleus; Cytoplasm
Applications Tested/Suitable for anti-FOXP3 antibody
ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin/ Paraffin, Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-FOXP3 antibody
ELISA: 1:15,000-1:20,000
Immunocytochemistry: 1:100
Immunofluorescence: 1:100
Immunohistochemistry: 1:100
Immunoprecipitation: 1:200
Western Blot: 1:500

Other Notes

Small volumes of anti-FOXP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FOXP3 purchase

MBS541629 is an antibody targeting FOXP3. Also known as FOXP3 Antibody BIOTIN. Reactive in Bovine, Cat, Human, Monkey, Mouse, Pig, Rat
Predicted: Pig, Cynomolgus monkey, Rhesus monkey, Deer. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FOXP3. It may not necessarily be applicable to this product.

NCBI GI #
47605552
NCBI GeneID
64776
NCBI Accession #
Q9H5F2.1
UniProt Primary Accession #
Q9H5F2
UniProt Secondary Accession #
Q6I9X7; Q9NQC6
UniProt Related Accession #
Q9H5F2
NCBI Official Full Name
UPF0686 protein C11orf1
NCBI Official Synonym Full Names
chromosome 11 open reading frame 1
NCBI Official Symbol
C11orf1
UniProt Protein Name
UPF0686 protein C11orf1
Protein Family
Forkhead box protein
UniProt Gene Name
C11orf1
UniProt Entry Name
CK001_HUMAN
NCBI Protein Information
UPF0686 protein C11orf1

UniProt Comments for FOXP3

C11orf1: Belongs to the UPF0686 family.

Chromosomal Location of Human Ortholog: 11q23.1

Cellular Component: nucleoplasm; nucleus

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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