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Receptor 2 (GABA B) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS541663

Affinity Purified Gamma-aminobutyric acid receptor subunit beta-2 Antibody C-epitopeComponent of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular… More details

$480 / 0.1 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
GABA B Receptor 2, Polyclonal Antibody
Full Product Name
GABA B Receptor 2 Antibody
Product Gene Name
Product Synonym Names
GABA-B-R2; Gamma aminobutyric acid (GABA) B receptor 2; Gb1; GPRC3A; Seven transmembrane helix receptor antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cat, Human
Form/Format
Affinity Purified
Concentration
0.55-0.75 ug/ul in antibody stabilization buffer (lot specific)
Preparation and Storage
-20 degree C for long term storage
Matching Pairs
Molecular Weight
42,741 Da
OMIM
600232
3D Structure
ModBase 3D Structure for P47870
Immunogen
Synthetic peptide taken within amino acid region 350-400 on human gamma-aminobutyric acid receptor subunit beta-2 protein.
Expression
Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression.
Determinant
C-epitope
Molecular Function
Chloride channel activity; GABA-A receptor activity; Inhibitory extracellular ligand-gated ion channel activity
Structure
Binds UBQLN1. Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents (By similarity). Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains.
Subcellular Location
Cell junction degree Synapse degree postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
Applications Tested/Suitable for anti-GABA B antibody
ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-GABA B antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunoprecipitation: 1:150
Western Blot: 1:500

Other Notes

Small volumes of anti-GABA B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GABA B purchase

MBS541663 is an antibody targeting GABA B. Also known as GABA B Receptor 2 Antibody. Reactive in Cat, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GABA B. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
gamma-aminobutyric acid receptor subunit beta-2 isoform 1
NCBI Official Synonym Full Names
gamma-aminobutyric acid type A receptor beta2 subunit
NCBI Official Symbol
GABRB2
UniProt Protein Name
Gamma-aminobutyric acid receptor subunit beta-2
UniProt Synonym Protein Names
GABA(A) receptor subunit beta-2
UniProt Gene Name
GABRB2
UniProt Entry Name
GBRB2_HUMAN
NCBI Protein Information
gamma-aminobutyric acid receptor subunit beta-2

NCBI Summary for GABA B

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion. [provided by RefSeq, Jul 2008]
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UniProt Comments for GABA B

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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