GCN2 Antibody – Rabbit Polyclonal

GCN2: a kinase of the PEK family. Phosphorylates and inhibits eukaryotic initiation factor (eIF)-2 alpha, providing an important protective mechanism during various cellular stress conditions including endoplasmic reticulum (ER) stress.

Protein type: EC 2.7.11.1; Protein kinase, Other; Translation; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Other group; PEK family; GCN2 subfamily

Cellular Component: cytoplasm; intracellular; polysome

Molecular Function: ATP binding; eukaryotic translation initiation factor 2alpha kinase activity; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; RNA binding; transferase activity; tRNA binding

Biological Process: adaptive immune response; cell cycle; cell cycle arrest; cell differentiation; cellular response to amino acid starvation; cellular response to starvation; defense response to virus; immune system process; inhibition of CREB transcription factor; learning; long-term memory; negative regulation of neuron differentiation; negative regulation of translation; negative regulation of translation initiation in response to stress; negative regulation of translational initiation; nervous system development; phosphorylation; positive regulation of adaptive immune response; positive regulation of defense response to virus by host; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of translation; regulation of translation initiation in response to stress; regulation of translational initiation; T cell activation during immune response; unfolded protein response; viral protein biosynthetic process; viral reproduction