Glucose Transporter GLUT4 (GLUT4) Antibody – Rabbit Polyclonal

GLUT4: an integral membrane facilitative glucose transporter. One of 13 members of the human equilibrative glucose transport protein family. Its surface expression is regulated by insulin. Has two internalization sequences, a dileucine repeat present in the C-terminus and a FxxY motif in the amino-terminal end. Associates with an intracellular tubulo-vesicular compartment under low plasma conditions. The binding of insulin to the insulin receptor (a typosine kinase) leads to the rapid translocation of GLUT4 to the cell surface, increasing cellular glucose transport activity. Its translocation to the plasma membrane is also stimulated by exercise, but independent from insulin signaling. This insulin-independent pathway may be regulated by AMPK.

Protein type: Transporter, SLC family; Transporter; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: cell surface; clathrin-coated vesicle; coated pit; cytoplasm; cytoplasmic vesicle membrane; cytosol; endomembrane system; endosome; external side of plasma membrane; integral to membrane; integral to plasma membrane; intracellular membrane-bound organelle; lipid raft; membrane; multivesicular body; perinuclear region of cytoplasm; plasma membrane; sarcolemma; T-tubule; trans-Golgi network transport vesicle; vesicle; vesicle membrane

Molecular Function: D-glucose transmembrane transporter activity; glucose transmembrane transporter activity; insulin-responsive hydrogen:glucose symporter activity; protein binding; substrate-specific transmembrane transporter activity; transmembrane transporter activity; transporter activity

Biological Process: amylopectin biosynthetic process; brown fat cell differentiation; carbohydrate transport; cellular response to insulin stimulus; glucose homeostasis; glucose transport; transmembrane transport; transport