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Granzyme B (GZMB) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS541776

This enzyme is necessary for target cell lysis in cell-mediated immune responses;Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. More details

$480 / 0.1 mg +1 FREE 8GB USB
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Granzyme B (GZMB), Polyclonal Antibody
Full Product Name
Granzyme B Antibody C-epitope
Product Gene Name
anti-GZMB antibody
Product Synonym Names
C11; Cathepsin G like 1; CCPI; CGL 1; CSP B; CTLA 1; CTSGL 1; Cytotoxic serine protease B; Cytotoxic T Lymphocyte Associated Serine Esterase 1; Cytotoxic T lymphocyte proteinase 2; Fragmentin 2; Granzyme B (granzyme 2, cytotoxic T lymphocyte associated serine esterase 1); Granzyme-2; GRB; GZMB; HLP; Human lymphocyte protein; Lymphocyte protease; Protease Serine B; SECT; T-cell serine protease 1-3E antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Monkey
Form/Format
Affinity Purified
Concentration
0.63 ug/ul in antibody stabilization buffer (lot specific)
Preparation and Storage
-20 degree C for long term storage
Matching Pairs
Antibody: Granzyme B (MBS541776)
Positive Control: Granzyme B (MBS542831)
Antibody/Peptide Pairs
Granzyme B peptide (MBS543795) is used for blocking the activity of Granzyme B antibody (MBS541776)
Molecular Weight
27,716 Da
OMIM
123910
3D Structure
ModBase 3D Structure for P10144
Immunogen
Synthetic peptide taken within amino acid region 50-100 on human endogenous Granzyme B protein.
Expression
leukocyte; adipose tissue; appendix; bladder; bone marrow; colon; duodenum; endometrium
Determinant
C-epitope
Molecular Function
Hydrolase, Protease, Serine protease
Subcellular Location
intracellular membrane-bounded organelle; nucleus; Cytoplasm

Product Categories/Family for anti-GZMB antibody

Primary Antibodies; Cell Biology; Apoptosis; Granzyme B Antibody
Applications Tested/Suitable for anti-GZMB antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-GZMB antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunoprecipitation: 1:150
Western Blot: 1:500

Western Blot (WB) of anti-GZMB antibody

Rabbit Anti-GZMB Polyclonal Antibody – Cat# MBS541776

Immunohistochemistry (IHC) of anti-GZMB antibody

Rabbit Anti-GZMB Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS541776

Other Notes

Small volumes of anti-GZMB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GZMB purchase

MBS541776 is an antibody targeting GZMB. Also known as Granzyme B Antibody C-epitope. Reactive in Human, Monkey. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GZMB. It may not necessarily be applicable to this product.

NCBI GI #
38532130
NCBI GeneID
3002
NCBI Accession #
AAR23323.1
UniProt Primary Accession #
P10144
UniProt Secondary Accession #
Q8N1D2; Q9UCC1
UniProt Related Accession #
P10144
NCBI Official Full Name
endogenous granzyme B
NCBI Official Synonym Full Names
granzyme B
NCBI Official Symbol
GZMB
NCBI Official Synonym Symbols
HLP; CCPI; CGL1; CSPB; SECT; CGL-1; CSP-B; CTLA1; CTSGL1
UniProt Protein Name
Granzyme B
UniProt Synonym Protein Names
C11; CTLA-1; Cathepsin G-like 1; CTSGL1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; HLP; SECT; T-cell serine protease 1-3E
Protein Family
Granzyme
UniProt Gene Name
GZMB
UniProt Synonym Gene Names
CGL1; CSPB; CTLA1; GRB; CTSGL1; Lymphocyte protease; HLP
UniProt Entry Name
GRAB_HUMAN
NCBI Protein Information
granzyme B

NCBI Summary for GZMB

Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. [provided by RefSeq, Jul 2008]
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UniProt Comments for GZMB

GZMB: This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. By staphylococcal enterotoxin A (SEA) in peripheral blood leukocytes. Inactivated by the serine protease inhibitor diisopropylfluorophosphate. Belongs to the peptidase S1 family. Granzyme subfamily.

Protein type: EC 3.4.21.79; Apoptosis; Protease

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: cytoplasm; cytosol; immunological synapse; intracellular membrane-bound organelle; membrane; mitochondrion; nucleus

Molecular Function: protein binding; serine-type endopeptidase activity; serine-type peptidase activity

Biological Process: apoptosis; cytolysis; natural killer cell mediated cytotoxicity; protein processing
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Research Articles on GZMB

1. Results reveal enhanced intra- and extracellular expression of gzmA and B in patients with pulmonary TB, suggesting that gzms are part of the host response to tuberculosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GZMB antibody

 Reference Product  PubMed Publications
 CASP3 antibody  >92 publications with GZMB and CASP3
 BID antibody  >46 publications with GZMB and BID
 SERPINB9 antibody  >39 publications with GZMB and SERPINB9
 PRF1 antibody  >36 publications with GZMB and PRF1
 FOXP3 antibody  >34 publications with GZMB and FOXP3
 CASP7 antibody  >13 publications with GZMB and CASP7
 IL2 antibody  >4 publications with GZMB and IL2
 CD8A antibody  >2 publications with GZMB and CD8A
 IL2RB antibody  >1 publications with GZMB and IL2RB

Pathways associated with anti-GZMB antibody

 Products by Pathway  Pathway Diagram
 Activation, Myristolyation Of BID And Translocation To Mitochondria Pathway antibodies  Activation, Myristolyation Of BID And Translocation To Mitochondria Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram

Diseases associated with anti-GZMB antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >137 publications with GZMB and Necrosis
 Inflammation Antibodies  >82 publications with GZMB and Inflammation
 Disease Models, Animal Antibodies  >59 publications with GZMB and Disease Models, Animal
 Nervous System Diseases Antibodies  >41 publications with GZMB and Nervous System Diseases
 Lung Diseases Antibodies  >41 publications with GZMB and Lung Diseases
 Neoplasms, Experimental Antibodies  >39 publications with GZMB and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >31 publications with GZMB and Cardiovascular Diseases
 Hypersensitivity Antibodies  >27 publications with GZMB and Hypersensitivity
 Breast Neoplasms Antibodies  >21 publications with GZMB and Breast Neoplasms
 Hepatitis Antibodies  >15 publications with GZMB and Hepatitis

Organs/Tissues associated with anti-GZMB antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >947 publications with GZMB and Blood
 Kidney Antibodies  >91 publications with GZMB and Kidney
 Lung Antibodies  >82 publications with GZMB and Lung
 Liver Antibodies  >79 publications with GZMB and Liver
 Spleen Antibodies  >76 publications with GZMB and Spleen
 Bone Marrow Antibodies  >54 publications with GZMB and Bone Marrow
 Heart Antibodies  >43 publications with GZMB and Heart
 Intestine Antibodies  >34 publications with GZMB and Intestine
 Pancreas Antibodies  >16 publications with GZMB and Pancreas
 Stomach Antibodies  >11 publications with GZMB and Stomach
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