Receptor (IP3) Antibody – Rabbit Polyclonal

This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009]

IP3R1: a multi-pass endoplasmic reticulum membrane receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaMKII, eventually leading to the activation of downstream apoptosis pathways. Part of a cGMP kinase signaling complex that includes alpha-actin, calponin H1, phospholamban, PKG1 and IP3R1. Widely expressed. The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. Phosphorylation by PKA prevents the ligand-induced opening of the calcium channels. Belongs to the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family. Eight alternatively spliced isoforms have been described.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 3p26.1

Cellular Component: calcineurin complex; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; membrane; nuclear inner membrane; nucleolus; platelet dense granule membrane; postsynaptic density; sarcoplasmic reticulum

Molecular Function: calcium channel inhibitor activity; calcium ion transmembrane transporter activity; calcium-release channel activity; inositol 1,4,5-triphosphate-sensitive calcium-release channel activity; phosphoinositide binding; protein binding

Biological Process: calcium ion transport; endoplasmic reticulum calcium ion homeostasis; epithelial fluid transport; inositol phosphate-mediated signaling; negative regulation of calcium-mediated signaling; platelet activation; post-embryonic development; regulation of autophagy; regulation of insulin secretion; release of sequestered calcium ion into cytosol; response to hypoxia; signal transduction; voluntary musculoskeletal movement