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LAT Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS541980

Required for TCR (T-cell antigen receptor) and pre-TCR-mediated signaling both in mature T-cells and during their development. More details

$610 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
LAT, Polyclonal Antibody
Full Product Name
LAT Antibody BIOTIN-Conjugated
Product Gene Name
Product Synonym Names
36 kDa phospho tyrosine adapter protein; LAT 1; lat; Linker for activation of T cells; p36 38; pp36 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
BIOTIN-Conjugated
Concentration
0.54-0.72 ug/ul in antibody stabilization buffer (lot specific)
Preparation and Storage
-20 degree C for long term storage
Matching Pairs
Antibody: LAT (MBS541980)
Positive Control: LAT (MBS542910)
Antibody/Peptide Pairs
LAT peptide (MBS543927) is used for blocking the activity of LAT antibody (MBS541980)
Molecular Weight
27,774 Da
OMIM
602354
3D Structure
ModBase 3D Structure for O43561
Immunogen
Synthetic peptide taken within amino acid region 40-90 on LAT protein.
Expression
Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level).
Molecular Function
Protein kinase binding, SH3/SH2 adaptor activity
Subcellular Location
Cell membrane, Single-pass type III membrane protein
Applications Tested/Suitable for anti-LAT antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-LAT antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Western Blot: 1:500

Other Notes

Small volumes of anti-LAT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LAT purchase

MBS541980 is an antibody targeting LAT. Also known as LAT Antibody BIOTIN-Conjugated. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for LAT. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
LAT
NCBI Official Synonym Full Names
linker for activation of T-cells
NCBI Official Symbol
LAT
NCBI Official Synonym Symbols
LAT1; pp36
UniProt Protein Name
Linker for activation of T-cells family member 1
UniProt Synonym Protein Names
36 kDa phospho-tyrosine adapter protein; pp36; p36-38
UniProt Gene Name
LAT
UniProt Synonym Gene Names
pp36
UniProt Entry Name
LAT_HUMAN
NCBI Protein Information
linker for activation of T-cells family member 1

NCBI Summary for LAT

The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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UniProt Comments for LAT

Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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