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NTAL Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS541982

BIOTIN-Conjugated Linker for activation of T-cells family member 2 AntibodyInvolved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells… More details

$610 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NTAL, Polyclonal Antibody
Full Product Name
LAT2 / NTAL Antibody BIOTIN-Conjugated
Product Gene Name
Product Synonym Names
HSPC046; LAB; LAT2; Linker for activation of B cells; Membrane associated adapter molecule; Non T cell activation linker; WBSCR 5; Wbscr15 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Monkey
Form/Format
BIOTIN-Conjugated
Concentration
0.54-0.72 ug/ul in antibody stabilization buffer (lot specific)
Preparation and Storage
-20 degree C for long term storage
Matching Pairs
Antibody: NTAL (MBS541982)
Positive Control: NTAL (MBS542911)
Antibody/Peptide Pairs
NTAL peptide (MBS543928) is used for blocking the activity of NTAL antibody (MBS541982)
Molecular Weight
12,255 Da
OMIM
605719
3D Structure
ModBase 3D Structure for Q9GZY6
Immunogen
Synthetic peptide taken within amino acid region 40-90 on LAT2 protein.
Expression
Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).
Molecular Function
SH2 domain binding
Structure
When phosphorylated, interacts with GRB2. May also interact with SOS1, GAB1 and CBL.
Subcellular Location
Cell membrane; Single-pass type III membrane protein
Applications Tested/Suitable for anti-NTAL antibody
ELISA (EIA), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-NTAL antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunohistochemistry: 1:200
Western Blot: 1:500

Other Notes

Small volumes of anti-NTAL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NTAL purchase

MBS541982 is an antibody targeting NTAL. Also known as LAT2 / NTAL Antibody BIOTIN-Conjugated. Reactive in Human, Monkey. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NTAL. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
linker for activation of T-cells family member 2
NCBI Official Synonym Full Names
linker for activation of T-cells family member 2
NCBI Official Symbol
LAT2
NCBI Official Synonym Symbols
LAB; NTAL; WSCR5; WBSCR5; HSPC046; WBSCR15
UniProt Protein Name
Linker for activation of T-cells family member 2
UniProt Synonym Protein Names
Linker for activation of B-cells; Membrane-associated adapter molecule; Non-T-cell activation linker; Williams-Beuren syndrome chromosomal region 15 protein; Williams-Beuren syndrome chromosomal region 5 protein
UniProt Gene Name
LAT2
UniProt Synonym Gene Names
LAB; NTAL; WBS15; WBSCR15; WBSCR5
UniProt Entry Name
NTAL_HUMAN
NCBI Protein Information
linker for activation of T-cells family member 2

NCBI Summary for NTAL

This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq, Jul 2008]

UniProt Comments for NTAL

LAB: linker for activation of B cells (LAB) is an adaptor protein. B cell antigen receptor signaling leads to its phosphorylation and interaction with the adaptor protein Grb2. Decreased expression leads to a reduction in BCR-mediated calcium flux and Erk activation. Localized to lipid rafts.

Protein type: Membrane protein, integral; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: integral to membrane; intracellular; lipid raft; mast cell granule; plasma membrane

Molecular Function: protein binding; SH2 domain binding

Biological Process: adaptive immune response; B cell activation; B cell receptor signaling pathway; calcium-mediated signaling; mast cell degranulation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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