Kinase 2 (LIM) Antibody – Chicken Polyclonal

This gene is a member of the Jumonji domain 2 (JMJD2) family. The encoded protein is a trimethylation-specific demethylase, and converts specific trimethylated histone residues to the dimethylated form. This enzymatic action regulates gene expression and chromosome segregation. Chromosomal aberrations and changes in expression of this gene may be found in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

JMJD2C: the histone demethylase implicated in the epigenetic reprogramming during the early embryogenesis. Preferentially expressed in undifferentiated ES cells. JMJD2C, along with JMJD1A, regulate self-renewal in embryonic stem cells. Specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Two isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.11.-; Demethylase; Oxidoreductase

Chromosomal Location of Human Ortholog: 9p24.1

Cellular Component: nuclear chromatin; nucleoplasm

Molecular Function: androgen receptor binding; dioxygenase activity; enzyme binding; histone demethylase activity; histone demethylase activity (H3-K9 specific); zinc ion binding

Biological Process: histone H3-K9 demethylation; positive regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent