MAP3K10 Antibody – Rabbit Polyclonal

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]

MLK2: a TKL kinase of the MLK family. A dual leucine zipper kinase. Phosphorylates and activates JNK and SEK1. Interacts with PAK and NCK. May be involved in nerve growth factor-induced neuronal apoptosis.

Protein type: Protein kinase, TKL; EC 2.7.11.25; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); TKL group; MLK family; MLK subfamily

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: cytoplasm

Molecular Function: ATP binding; bHLH transcription factor binding; JUN kinase kinase kinase activity; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; transcription corepressor activity

Biological Process: activation of JNK activity; activation of JNKK activity; apoptosis; JNK cascade; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of apoptosis; positive regulation of JNK activity; positive regulation of JNK cascade; protein amino acid autophosphorylation; signal transduction; smoothened signaling pathway