MOR1 Antibody – Rabbit Polyclonal

This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013]

MOR-1: a Gi-protein-coupled receptor for beta-endorphin, morphine and other opiates. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Ligand-binding inactivates adenylyl cyclase, and activates a variety of G-beta-gamma-dependent pathways including the MAPK and the PI3K/Akt cascades. Two splice-variant isoforms have been described.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6q24-q25

Cellular Component: cell; dendrite cytoplasm; endoplasmic reticulum; focal adhesion; Golgi apparatus; integral to plasma membrane; lipid raft; neuron projection; perikaryon; plasma membrane; sarcolemma

Molecular Function: beta-endorphin receptor activity; filamin binding; G-protein alpha-subunit binding; G-protein beta-subunit binding; G-protein coupled receptor activity; neuropeptide binding; protein binding; protein C-terminus binding; protein domain specific binding; voltage-gated calcium channel activity

Biological Process: acute inflammatory response to antigenic stimulus; behavioral response to ethanol; cellular response to stress; dopamine receptor, adenylate cyclase activating pathway; eating behavior; elevation of cytosolic calcium ion concentration; G-protein signaling, coupled to cyclic nucleotide second messenger; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); locomotory behavior; negative regulation of adenylate cyclase activity; negative regulation of cell proliferation; negative regulation of nitric oxide biosynthetic process; neuropeptide signaling pathway; opioid receptor, adenylate cyclase inhibiting pathway; positive regulation of appetite; positive regulation of neurogenesis; positive regulation of nitric oxide biosynthetic process; reduction of cytosolic calcium ion concentration; regulation of excitatory postsynaptic membrane potential; regulation of sensory perception of pain; response to cocaine; response to food; response to lipopolysaccharide; response to radiation; sensory perception; sensory perception of pain; synaptic transmission; wound healing

Disease: Epilepsy, Idiopathic Generalized