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MRP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS542136

BIOTIN-Conjugated Multidrug resistance-associated protein 1 AntibodyMediates export of organic anions and drugs from the cytoplasm. More details

$610 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MRP1, Polyclonal Antibody
Full Product Name
MRP1 Antibody BIOTIN-Conjugated
Product Gene Name
anti-MRP1 antibody
Product Synonym Names
ABC29; ABCC; ABCC1; ATP binding cassette sub family C (CFTR/MRP) member 1; ATP binding cassette sub-family C member 1; DKFZ antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
BIOTIN-Conjugated
Concentration
0.5 ug/ul in antibody stabilization buffer (lot specific)
Preparation and Storage
-20 degree C for long term storage
Matching Pairs
Antibody: MRP1 (MBS542136)
Positive Control: MRP1 (MBS542963)
Antibody/Peptide Pairs
MRP1 peptide (MBS544000) is used for blocking the activity of MRP1 antibody (MBS542136)
Molecular Weight
170,496 Da
3D Structure
ModBase 3D Structure for Q8CG09
Immunogen
Synthetic peptide corresponding to unique amino acid sequences on rat multidrug resistance-associated protein 1.
Immunoglobulin
IgG
Expression
Skeletal muscle, brain, heart, spleen, lung and kidney.
Molecular Function
Hydrolase
Structure
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Subcellular Location
Cell membrane, Membrane
Applications Tested/Suitable for anti-MRP1 antibody
ELISA (EIA), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-MRP1 antibody
ELISA: 1:20,000
Immunocytochemistry: 1:100
Immunofluorescence: 1:100
Immunohistochemistry: 1:100
Immunoprecipitation: 1:200
Western Blot: 1:500

Other Notes

Small volumes of anti-MRP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MRP1 purchase

MBS542136 is an antibody targeting MRP1. Also known as MRP1 Antibody BIOTIN-Conjugated. Reactive in Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MRP1. It may not necessarily be applicable to this product.

NCBI GI #
31542029
NCBI GeneID
24565
NCBI Accession #
NP_071617.2
UniProt Primary Accession #
Q8CG09
UniProt Secondary Accession #
Q63346; Q810E4; Q810G9; Q9JHS0
UniProt Related Accession #
Q8CG09
GenBank Nucleotide #
NM_022281.2
NCBI Official Full Name
multidrug resistance-associated protein 1
NCBI Official Synonym Full Names
ATP binding cassette subfamily C member 1
NCBI Official Symbol
Abcc1
NCBI Official Synonym Symbols
Mrp; Mrp1; Abcc1a; Avcc1a
UniProt Protein Name
Multidrug resistance-associated protein 1
UniProt Synonym Protein Names
ATP-binding cassette sub-family C member 1; Leukotriene C(4) transporter; LTC4 transporter
Protein Family
37S ribosomal protein
UniProt Gene Name
Abcc1
UniProt Synonym Gene Names
Mrp1; LTC4 transporter
UniProt Entry Name
MRP1_RAT
NCBI Protein Information
multidrug resistance-associated protein 1

NCBI Summary for MRP1

ATP-binding cassette (ABC) multiple drug resistance protein involved in the release of glutathione synthase during oxidative stress [RGD, Feb 2006]

UniProt Comments for MRP1

ABCC1: a multi-pass membrane protein. A multidrug resistance member of the ABC transporter family that confers resistance to anticancer drugs. A multi-pass membrane protein. Exports sphingosine-1-phosphate (S1P), a potent inflammatory mediator, from mast cells during mast cell-mediated immune responses. Nine alternatively spliced human isoforms have been reported.

Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ABC family

Cellular Component: basolateral plasma membrane; cytoplasm; integral to plasma membrane; membrane; plasma membrane

Molecular Function: ATP binding; ATPase activity; drug transporter activity; efflux transmembrane transporter activity; glutathione S-conjugate-exporting ATPase activity; lipid-transporting ATPase activity; long-chain fatty acid transporter activity; oxidoreductase activity; sphingolipid transporter activity; xenobiotic-transporting ATPase activity

Biological Process: daunorubicin transport; drug export; multidrug transport; phospholipid efflux; plasma membrane long-chain fatty acid transport; positive regulation of cell migration; response to drug; response to oxidative stress; transmembrane transport; xenobiotic transport
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Research Articles on MRP1

1. Sonication enhanced sensitivity of glioma tumor cells to doxorubicin by down-regulating the expressions of p-glycoprotein and multidrug resistance protein 1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MRP1 antibody

 Reference Product  PubMed Publications
 Abcg2 antibody  >317 publications with MRP1 and Abcg2
 Abcg1 antibody  >15 publications with MRP1 and Abcg1
 Abca2 antibody  >10 publications with MRP1 and Abca2
 Abca7 antibody  >9 publications with MRP1 and Abca7
 Abcg8 antibody  >7 publications with MRP1 and Abcg8
 Slc22a8 antibody  >4 publications with MRP1 and Slc22a8
 Notch1 antibody  >2 publications with MRP1 and Notch1
 Spns2 antibody  >1 publications with MRP1 and Spns2

Pathways associated with anti-MRP1 antibody

 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway antibodies  Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway Diagram
 Irinotecan Pathway antibodies  Irinotecan Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Metabolism Of Water-soluble Vitamins And Cofactors Pathway antibodies  Metabolism Of Water-soluble Vitamins And Cofactors Pathway Diagram

Diseases associated with anti-MRP1 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >58 publications with MRP1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >37 publications with MRP1 and Lung Neoplasms
 Nervous System Diseases Antibodies  >35 publications with MRP1 and Nervous System Diseases
 Brain Diseases Antibodies  >33 publications with MRP1 and Brain Diseases
 Adenocarcinoma Antibodies  >31 publications with MRP1 and Adenocarcinoma
 Disease Models, Animal Antibodies  >26 publications with MRP1 and Disease Models, Animal
 Liver Diseases Antibodies  >26 publications with MRP1 and Liver Diseases
 Disease Progression Antibodies  >19 publications with MRP1 and Disease Progression
 Liver Neoplasms Antibodies  >18 publications with MRP1 and Liver Neoplasms
 Cardiovascular Diseases Antibodies  >17 publications with MRP1 and Cardiovascular Diseases

Organs/Tissues associated with anti-MRP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >83 publications with MRP1 and Brain
 Liver Antibodies  >69 publications with MRP1 and Liver
 Kidney Antibodies  >55 publications with MRP1 and Kidney
 Embryonic Tissue Antibodies  >10 publications with MRP1 and Embryonic Tissue
 Prostate Antibodies  >9 publications with MRP1 and Prostate
 Ovary Antibodies  >7 publications with MRP1 and Ovary
 Eye Antibodies  >5 publications with MRP1 and Eye
 Thymus Antibodies  >4 publications with MRP1 and Thymus
 Pancreas Antibodies  >2 publications with MRP1 and Pancreas
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