MURF1 Antibody – Rabbit Polyclonal

This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012]

MURF1: E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric- associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ubiquitin conjugating system; Ligase; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 1p34-p33

Cellular Component: cytoplasm; M band; microtubule; nucleus; Z disc

Molecular Function: ligase activity; protein binding; signal transducer activity; titin binding; ubiquitin-protein ligase activity; zinc ion binding

Biological Process: muscle contraction; protein ubiquitination; response to electrical stimulus involved in regulation of muscle adaptation; response to glucocorticoid stimulus; signal transduction; skeletal muscle atrophy