MyoD1 Antibody – Rabbit Polyclonal

This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. [provided by RefSeq, Jul 2008]

MyoD: a transcription factor of the basic helix-loop-helix family and the myogenic factors subfamily. Involved in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. It is involved in muscle cell differentiation, and is essential for repair of damaged tissue. It activates its own transcription which may stabilize commitment to myogenesis.

Protein type: Transcription factor; DNA-binding; RNA splicing

Chromosomal Location of Human Ortholog: 11p15.4

Cellular Component: cytoplasm; myofibril; nuclear chromatin; nucleoplasm; nucleus; transcription factor complex

Molecular Function: chromatin binding; chromatin DNA binding; nuclear hormone receptor binding; protein binding; protein heterodimerization activity; RNA polymerase II transcription factor activity, enhancer binding; transcription coactivator activity; transcription factor binding; ubiquitin protein ligase binding

Biological Process: cellular response to starvation; muscle cell fate commitment; muscle development; myoblast cell fate determination; myoblast fusion; myotube cell development; myotube differentiation involved in skeletal muscle regeneration; positive regulation of muscle cell differentiation; positive regulation of myoblast differentiation; positive regulation of skeletal muscle fiber development; positive regulation of skeletal muscle regeneration; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; regulation of alternative nuclear mRNA splicing, via spliceosome; regulation of RNA splicing; regulation of transcription from RNA polymerase II promoter; skeletal muscle development; skeletal muscle fiber adaptation; skeletal muscle fiber development; transcription from RNA polymerase II promoter