Nicotinic Acetylcholine Receptor Alpha 7 (CHRNA7) Antibody – Rabbit Polyclonal

nAChRA7: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 7/CHRNA7 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, ligand-gated; Channel, cation

Cellular Component: apical plasma membrane; asymmetric synapse; axolemma; axon; cell junction; cell soma; cytoplasm; dendrite; dendritic shaft; dendritic spine; external side of plasma membrane; growth cone; integral to membrane; lipid raft; membrane; nicotinic acetylcholine-gated receptor-channel complex; plasma membrane; postsynaptic density; postsynaptic membrane; presynaptic membrane

Molecular Function: acetylcholine binding; acetylcholine receptor activity; acetylcholine-gated cation channel activity; adenylate cyclase binding; ATPase binding; beta-amyloid binding; chloride channel regulator activity; drug binding; nicotinic acetylcholine-activated cation-selective channel activity; protein binding; protein homodimerization activity; protein kinase binding; toxin binding

Biological Process: activation of MAPK activity; associative learning; B cell activation; behavioral response to ethanol; behavioral response to nicotine; calcium ion transport; cellular calcium ion homeostasis; cognition; dopamine biosynthetic process; endocytosis; generation of action potential; generation of ovulation cycle rhythm; ion transport; memory; negative regulation of inflammatory response; negative regulation of interleukin-1 beta production; negative regulation of interleukin-6 production; negative regulation of tumor necrosis factor production; ovulation cycle; positive regulation of angiogenesis; positive regulation of cell proliferation; positive regulation of heart rate in baroreceptor response to decreased systemic arterial blood pressure; regulation of inflammatory response; regulation of membrane potential; regulation of norepinephrine secretion; regulation of synaptic transmission, dopaminergic; response to ethanol; response to food; response to hypoxia; response to nicotine; signal transduction; sperm motility; synaptic transmission, cholinergic; T cell activation