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NKG2D Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS542218

BIOTIN-Conjugated NKG2-D type II integral membrane protein AntibodyFunction as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells… More details

$610 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NKG2D, Polyclonal Antibody
Full Product Name
NKG2D Antibody BIOTIN-Conjugated
Product Gene Name
anti-NKG2D antibody
Product Synonym Names
CD314; D12S2489E; Killer cell lectin like receptor subfamily K member 1; KLR; NK cell receptor D; NK lectin-like receptor; NKG2 D activating NK receptor; NKLLR; NKR P2 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Bovine, Human, Monkey, Panda
Form/Format
BIOTIN-Conjugated
Concentration
0.55 ug/ul in antibody stabilization buffer (lot specific)
Preparation and Storage
-20 degree C for long term storage
Matching Pairs
Antibody: NKG2D (MBS542218)
Positive Control: NKG2D (MBS542991)
Antibody/Peptide Pairs
NKG2D peptide (MBS544043) is used for blocking the activity of NKG2D antibody (MBS542218)
Molecular Weight
24,438 Da
3D Structure
ModBase 3D Structure for O70215
Immunogen
Synthetic peptide taken within amino acid region 180-230 on rat NKG2D protein.
Expression
Expressed by natural killer cells and by resting thoracic duct CD4+ and CD8+ T-cells, but not by thymocytes or other hemopoietic cells. Expressed by DC cells
Molecular Function
MHC class Ib receptor activity
Subcellular Location
Cell membrane, Membrane
Applications Tested/Suitable for anti-NKG2D antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-NKG2D antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Western Blot: 1:500

Other Notes

Small volumes of anti-NKG2D antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NKG2D purchase

MBS542218 is an antibody targeting NKG2D. Also known as NKG2D Antibody BIOTIN-Conjugated. Reactive in Bovine, Human, Monkey, Panda. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NKG2D. It may not necessarily be applicable to this product.

NCBI GI #
19424150
NCBI GeneID
24934
NCBI Accession #
NP_598196.1
UniProt Primary Accession #
O70215
UniProt Related Accession #
O70215
GenBank Nucleotide #
NM_133512.2
NCBI Official Full Name
NKG2-D type II integral membrane protein
NCBI Official Synonym Full Names
killer cell lectin like receptor K1
NCBI Official Symbol
Klrk1
NCBI Official Synonym Symbols
NKG2D; Nkrp2
UniProt Protein Name
NKG2-D type II integral membrane protein
UniProt Synonym Protein Names
Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NK lectin-like receptor; NKLLR; NKG2-D-activating NK receptor; NKR-P2; CD_antigen: CD314
Protein Family
NKG2D ligand
UniProt Gene Name
Klrk1
UniProt Synonym Gene Names
Nkg2d; Nkrp2; NKLLR
UniProt Entry Name
NKG2D_RAT
NCBI Protein Information
NKG2-D type II integral membrane protein

NCBI Summary for NKG2D

functions as a natural cytotoxicity receptor to stimulate perforin-mediated elimination of ligand-expressing tumor cells [RGD, Feb 2006]

UniProt Comments for NKG2D

Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8+ T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins.
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Research Articles on NKG2D

1. Blockade of NKG2D significantly attenuated ischemia-reperfusion injury in a cardiac transplantation model.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NKG2D antibody

 Reference Product  PubMed Publications
 Hcst antibody  >44 publications with NKG2D and Hcst
 Rae1 antibody  >43 publications with NKG2D and Rae1
 Tyrobp antibody  >12 publications with NKG2D and Tyrobp
 Vav1 antibody  >11 publications with NKG2D and Vav1

Pathways associated with anti-NKG2D antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram

Diseases associated with anti-NKG2D antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >86 publications with NKG2D and Carcinoma
 Inflammation Antibodies  >62 publications with NKG2D and Inflammation
 Necrosis Antibodies  >56 publications with NKG2D and Necrosis
 Neoplasms, Experimental Antibodies  >42 publications with NKG2D and Neoplasms, Experimental
 Melanoma Antibodies  >40 publications with NKG2D and Melanoma
 Cardiovascular Diseases Antibodies  >35 publications with NKG2D and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >26 publications with NKG2D and Nervous System Diseases
 Lung Neoplasms Antibodies  >25 publications with NKG2D and Lung Neoplasms
 Ovarian Neoplasms Antibodies  >22 publications with NKG2D and Ovarian Neoplasms
 Neoplasm Metastasis Antibodies  >22 publications with NKG2D and Neoplasm Metastasis

Organs/Tissues associated with anti-NKG2D antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >5 publications with NKG2D and Eye
 Pancreas Antibodies  >3 publications with NKG2D and Pancreas
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