NKX2.2 Antibody – Rabbit Polyclonal

The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. [provided by RefSeq, Jul 2008]

NKX2-2: Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter. Belongs to the NK-2 homeobox family.

Protein type: Transcription factor; Cell development/differentiation

Chromosomal Location of Human Ortholog: 20p11.22

Cellular Component: nucleoplasm

Molecular Function: chromatin binding; sequence-specific DNA binding; transcription coactivator activity; transcription factor activity; transcription factor binding

Biological Process: astrocyte differentiation; brain development; endocrine pancreas development; gut development; negative regulation of neuron differentiation; neuron fate specification; oligodendrocyte development; optic nerve development; positive regulation of neuron differentiation; positive regulation of oligodendrocyte differentiation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; response to glucose stimulus; response to progesterone stimulus; smoothened signaling pathway; spinal cord motor neuron differentiation; spinal cord oligodendrocyte cell fate specification; transcription, DNA-dependent