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NTH1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS542252

FITC-Conjugated NTH endonuclease III-like 1 Antibody C-epitopeBifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of… More details

$610 / 0.1 mg +1 FREE 8GB USB
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NTH1, Polyclonal Antibody
Full Product Name
NTH1 Antibody FITC-Conjugated
Product Gene Name
anti-NTH1 antibody
Product Synonym Names
Bifunctional DNA N glycoslyase/DNA (apurinic or apyrimidinic site) lyase; DNA glycoslyase/AP lyase; Endonuclease III like protein 1; hNTH1; NTH 1; OCTS 3 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
FITC-Conjugated
Concentration
0.64-0.72 ug/ul in antibody stabilization buffer (lot specific)
Preparation and Storage
-20 degree C for long term storage
Antibody/Peptide Pairs
NTH1 peptide (MBS544061) is used for blocking the activity of NTH1 antibody (MBS542252)
Molecular Weight
32,839 Da
OMIM
602656
3D Structure
ModBase 3D Structure for P78549
Immunogen
C-epitope synthetic peptide taken within amino acid region 190-290 on human NTHL1 protein.
Expression
highest levels in heart and lowest levels in lung and liver
Determinant
C-epitope
Molecular Function
Glycosidase, Hydrolase, Lyase
Structure
Belongs to the Nth/MutY family
Subcellular Location
Nucleus. Mitochondrion
Applications Tested/Suitable for anti-NTH1 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-NTH1 antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Western Blot: 1:500

Other Notes

Small volumes of anti-NTH1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NTH1 purchase

MBS542252 is an antibody targeting NTH1. Also known as NTH1 Antibody FITC-Conjugated. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NTH1. It may not necessarily be applicable to this product.

NCBI GI #
29840795
NCBI GeneID
4913
NCBI Accession #
P78549.2
UniProt Primary Accession #
P78549
UniProt Secondary Accession #
Q1MVR1; Q99566; Q99794; Q9BPX2
UniProt Related Accession #
P78549
GenBank Nucleotide #
NM_002528.5
NCBI Official Full Name
Endonuclease III-like protein 1
NCBI Official Synonym Full Names
nth-like DNA glycosylase 1
NCBI Official Symbol
NTHL1
NCBI Official Synonym Symbols
FAP3; NTH1; OCTS3; hNTH1
UniProt Protein Name
Endonuclease III-like protein 1
UniProt Synonym Protein Names
Bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase
Protein Family
Endonuclease
UniProt Gene Name
NTHL1
UniProt Synonym Gene Names
hNTH1; DNA glycoslyase/AP lyase
UniProt Entry Name
NTH_HUMAN
NCBI Protein Information
endonuclease III-like protein 1

NCBI Summary for NTH1

The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity. [provided by RefSeq, Oct 2008]
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UniProt Comments for NTH1

NTHL1: Has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Incises damaged DNA at cytosines, thymines and guanines. Acts on a damaged strand, 5' from the damaged site. Required for the repair of both oxidative DNA damage and spontaneous mutagenic lesions. Belongs to the Nth/MutY family.

Protein type: DNA repair, damage; Mitochondrial; Hydrolase; EC 4.2.99.18; Lyase

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: mitochondrion; nucleoplasm; nucleus

Molecular Function: 4 iron, 4 sulfur cluster binding; DNA N-glycosylase activity; DNA-(apurinic or apyrimidinic site) lyase activity; double-stranded DNA binding; endonuclease activity; metal ion binding; oxidized purine base lesion DNA N-glycosylase activity; oxidized pyrimidine base lesion DNA N-glycosylase activity; protein binding

Biological Process: base-excision repair, AP site formation; depyrimidination; nucleotide-excision repair, DNA incision, 5'-to lesion; positive regulation of defense response to virus by host

Disease: Familial Adenomatous Polyposis 3
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Research Articles on NTH1

1. This study extends the description of biallelic mutations in NTHL1 beyond the single c.268C-->T,p.Q90* mutation that was observed previously.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-NTH1 antibody

 Products by Pathway  Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base-Excision Repair, AP Site Formation Pathway antibodies  Base-Excision Repair, AP Site Formation Pathway Diagram
 Cleavage Of The Damaged Pyrimidine Pathway antibodies  Cleavage Of The Damaged Pyrimidine Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Depyrimidination Pathway antibodies  Depyrimidination Pathway Diagram
 Displacement Of DNA Glycosylase By APEX1 Pathway antibodies  Displacement Of DNA Glycosylase By APEX1 Pathway Diagram
 Recognition And Association Of DNA Glycosylase With Site Containing An Affected Pyrimidine Pathway antibodies  Recognition And Association Of DNA Glycosylase With Site Containing An Affected Pyrimidine Pathway Diagram
 Resolution Of Abasic Sites (AP Sites) Pathway antibodies  Resolution Of Abasic Sites (AP Sites) Pathway Diagram

Diseases associated with anti-NTH1 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >6 publications with NTH1 and Nervous System Diseases
 Brain Diseases Antibodies  >2 publications with NTH1 and Brain Diseases
 Lung Diseases Antibodies  >2 publications with NTH1 and Lung Diseases
 Neoplasms, Experimental Antibodies  >2 publications with NTH1 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >2 publications with NTH1 and Kidney Diseases
 Adenomatous Polyposis Coli Antibodies  >2 publications with NTH1 and Adenomatous Polyposis Coli
 Cardiovascular Diseases Antibodies  >1 publications with NTH1 and Cardiovascular Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with NTH1 and Cell Transformation, Neoplastic
 Anemia Antibodies  >1 publications with NTH1 and Anemia
 Heart Diseases Antibodies  >1 publications with NTH1 and Heart Diseases

Organs/Tissues associated with anti-NTH1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with NTH1 and Blood
 Liver Antibodies  >3 publications with NTH1 and Liver
 Lung Antibodies  >3 publications with NTH1 and Lung
 Kidney Antibodies  >3 publications with NTH1 and Kidney
 Bone Antibodies  >1 publications with NTH1 and Bone
 Lymph Antibodies  >1 publications with NTH1 and Lymph
 Pharynx Antibodies  >1 publications with NTH1 and Pharynx
 Muscle Antibodies  >1 publications with NTH1 and Muscle
 Testis Antibodies  >1 publications with NTH1 and Testis
 Stomach Antibodies  >1 publications with NTH1 and Stomach
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