Netrin 1 (NTN1) Antibody – Rabbit Polyclonal

Netrin-1 (NTRN1) also known as axonal guidance protein (NTRN1) is a diffuse protein made by the floor plate cells that belongs to the Netrin family of proteins that guides axons to or away from the midline of the developing nervous system. In mammals, netrins are ligands for DCC receptor and the UNC5 receptor homologues. Netrin-1, located at human chromosome 17p13-p12, attracts spinal commissural axons and repels trochlear axons in vitro. In mice, deficiencies in Netrin-1 led to defects in spinal commissural axon projections. In the dorsal and intermediate spinal cord, it prevents DRG axons from being directed towards the dorsal spinal cord. Netrin-1 and its associated receptors playa key role cell death and tumor formation. Netrin-1/receptor pair induces apoptosis in cultured cells and also acts as regulators of tumor development. These properties of Netrin-1 have been implicated in colorectal tumorigenesis by regulating apoptosis. In the embryo, Netrin-1 is widely expressed in the developing nervous system and in mesodermal tissues. In adults, it is highly expressed in heart, small intestine, colon, liver and prostrate. It is also expressed in brain tumors and neuroblastomas. Netrin-1 is approximately a 73kDa protein.

The Netrin1-selective antibody (MBS540531) was generated against a peptide near C-terminal end of the Netrin1 protein using cyclic peptide methodology for generating antibodies, which results in higher titer and specificity. MBS540531 was used to develop FITC-conjugated NTRN1-selective antibodies (MBS542254). Western blot positive control samples and antigenic blocking pep/tide are available. The affinity purified mono-specific polyclonal antibody to NTRN1 strongly labels a 73kDa protein in western blot positive control (MBS543004) samples and in various tissues examined. Antibodies can be conjugated to secondary enzymes or fluorescent probes upon request as an additional charge.

Small volumes of anti-NTN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS542253 is an antibody targeting NTN1. Also known as Netrin 1 Antibody BIOTIN-Conjugated. Reactive in Human, Mouse, Rat. Host: Rabbit.