KAT13C / NCOA2 Antibody – Rabbit Polyclonal

SRC-2: a transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Present in a complex with CARM1 and p300. Present in a complex containing NCOA3, IKKA, IKKB, IKBKG and CREBBP. Interacts with HIF1A, NCOA1, APEX and NR3C1. Interacts with CASP8AP2. Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the MYST3-NCOA2 oncogene, which consists of the N-terminus part of MYST3/MOZ and the C-terminus part of NCOA2/TIF2. MYST3-NCOA2 binds to CREBBP and disrupts its function in transcription activation. Phosphorylated and potentiated by the p38 MAPK signaling cascade in vitro and in vivo.

Protein type: Nuclear receptor co-regulator; Motility/polarity/chemotaxis; Transcription, coactivator/corepressor

Cellular Component: cell soma; cytoplasm; dendrite; dendritic spine; Golgi apparatus; microtubule; nucleoplasm; nucleus; postsynaptic density; presynaptic active zone; rough endoplasmic reticulum

Molecular Function: chromatin binding; estrogen receptor binding; glucocorticoid receptor binding; histone acetyltransferase activity; ligand-dependent nuclear receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; PDZ domain binding; progesterone receptor binding; protein binding; protein complex binding; protein dimerization activity; receptor binding; retinoic acid receptor binding; retinoid X receptor binding; thyroid hormone receptor binding; thyroid hormone receptor coactivator activity; transcription coactivator activity; transcription factor binding

Biological Process: cellular response to hormone stimulus; circadian regulation of gene expression; intracellular receptor-mediated signaling pathway; locomotor rhythm; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of female receptivity; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; rhythmic process; transcription, DNA-dependent