PDE3A Antibody – Rabbit Polyclonal

This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

PDE3A: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Inhibited by cGMP. Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily.

Protein type: Nucleotide Metabolism - purine; Membrane protein, integral; Phosphodiesterase; Membrane protein, multi-pass; EC 3.1.4.17

Chromosomal Location of Human Ortholog: 12p12

Cellular Component: cytosol; integral to membrane

Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; cAMP binding; cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; metal ion binding

Biological Process: cAMP catabolic process; cAMP-mediated signaling; cGMP-mediated signaling; diterpenoid metabolic process; lipid metabolic process; negative regulation of apoptosis; negative regulation of vascular permeability; oocyte maturation; positive regulation of vascular permeability; regulation of meiosis; response to cAMP; response to drug

Disease: Hypertension And Brachydactyly Syndrome