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PDE4B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS543493

BIOTIN-Conjugated cAMP-specific 3', 5'-cyclic phosphodiesterase 4B Antibody C-epitopeHydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of… More details

$610 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PDE4B, Polyclonal Antibody
Full Product Name
Pan PDE4B Antibody BIOTIN-Conjugated
Product Gene Name
anti-PDE4B antibody
Product Synonym Names
5''-cyclic phosphodiesterase 4B; cAMP-specific 3''; cAMP-specific 3', 5'-cyclic phosphodiesterase 4B; DPDE4; dunce-like phosphodiesterase E4; MGC126529; PDE 4B; PDE IVB; PDE32; PDE4B5; PDEIVB; Phosphodiesterase 4B; Phosphodiesterase-4B cAMP-specific (dunce (Drosophila)-homolog) antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
BIOTIN-Conjugated
Concentration
0.68 ug/ul in antibody stabilization buffer (lot specific)
Specificity
This antibody detects all PDE4B proteins, including PDE4B1, PDE4B2, PDE4B3, and a 66 kDa PDE4B variant. It does not cross-react with other PDE family members such as PDE4A, PDE4C, or PDE4D.
Preparation and Storage
-20 degree C for long term storage
Antibody/Peptide Pairs
PDE4B peptide (MBS544198) is used for blocking the activity of PDE4B antibody (MBS543493)
Molecular Weight
57,709 Da
OMIM
600127
3D Structure
ModBase 3D Structure for Q07343
Immunogen
Synthetic peptide common to all PDE4B subtypes taken near C-terminal
Expression
Expressed in brain, heart, lung and skeletal muscle.
Determinant
C-epitope
Molecular Function
Hydrolase, 3', 5'-cyclic-AMP phosphodiesterase activity, cAMP binding
Applications Tested/Suitable for anti-PDE4B antibody
Confocal Microscopy (CM), ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-PDE4B antibody
Confocal Microscopy||1:250
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunocytochemistry: 1:250
Immunofluorescence: 1:250
Immunohistochemistry: 1:250
Immunoprecipitation: 1:350
Western Blot: 1:500-1:1,000

Other Notes

Small volumes of anti-PDE4B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PDE4B purchase

MBS543493 is an antibody targeting PDE4B. Also known as Pan PDE4B Antibody BIOTIN-Conjugated. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PDE4B. It may not necessarily be applicable to this product.

NCBI GI #
729163
NCBI GeneID
5142
NCBI Accession #
Q07343.1
UniProt Primary Accession #
Q07343
UniProt Secondary Accession #
O15443; Q13945; Q5TEK4; Q5TEK5; Q5TEK6; A5YW33
UniProt Related Accession #
Q07343
NCBI Official Full Name
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
NCBI Official Synonym Full Names
phosphodiesterase 4B
NCBI Official Symbol
PDE4B
NCBI Official Synonym Symbols
DPDE4; PDEIVB
UniProt Protein Name
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
UniProt Synonym Protein Names
DPDE4; PDE32
Protein Family
cAMP-specific 3',5'-cyclic phosphodiesterase
UniProt Gene Name
PDE4B
UniProt Synonym Gene Names
DPDE4
UniProt Entry Name
PDE4B_HUMAN
NCBI Protein Information
cAMP-specific 3',5'-cyclic phosphodiesterase 4B

NCBI Summary for PDE4B

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
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UniProt Comments for PDE4B

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.

Research Articles on PDE4B

1. Our results suggest that PDE4B does not play an important role during the chemotactic response of human neutrophils

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PDE4B antibody

 Reference Product  PubMed Publications
 ADCY9 antibody  >1 publications with PDE4B and ADCY9
 ADCY2 antibody  >1 publications with PDE4B and ADCY2
 ADCY7 antibody  >1 publications with PDE4B and ADCY7

Pathways associated with anti-PDE4B antibody

 Products by Pathway  Pathway Diagram
 DARPP-32 Events Pathway antibodies  DARPP-32 Events Pathway Diagram
 G Protein Signaling Pathways antibodies  G Protein Signaling Pathways Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Opioid Signalling Pathway antibodies  Opioid Signalling Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram

Diseases associated with anti-PDE4B antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >47 publications with PDE4B and Inflammation
 Schizophrenia Antibodies  >47 publications with PDE4B and Schizophrenia
 Necrosis Antibodies  >43 publications with PDE4B and Necrosis
 Disease Models, Animal Antibodies  >22 publications with PDE4B and Disease Models, Animal
 Nervous System Diseases Antibodies  >19 publications with PDE4B and Nervous System Diseases
 Asthma Antibodies  >17 publications with PDE4B and Asthma
 Bipolar Disorder Antibodies  >14 publications with PDE4B and Bipolar Disorder
 Nausea Antibodies  >7 publications with PDE4B and Nausea
 Vomiting Antibodies  >5 publications with PDE4B and Vomiting
 Memory Disorders Antibodies  >5 publications with PDE4B and Memory Disorders

Organs/Tissues associated with anti-PDE4B antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >69 publications with PDE4B and Brain
 Blood Antibodies  >67 publications with PDE4B and Blood
 Muscle Antibodies  >34 publications with PDE4B and Muscle
 Lung Antibodies  >23 publications with PDE4B and Lung
 Heart Antibodies  >14 publications with PDE4B and Heart
 Kidney Antibodies  >12 publications with PDE4B and Kidney
 Vascular Antibodies  >10 publications with PDE4B and Vascular
 Bone Antibodies  >8 publications with PDE4B and Bone
 Testis Antibodies  >8 publications with PDE4B and Testis
 Liver Antibodies  >7 publications with PDE4B and Liver
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