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PDE9A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS543576

BIOTIN-Conjugated High affinity cGMP-specific 3', 5'-cyclic phosphodiesterase 9A isoform a AntibodyHydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction. More details

$610 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PDE9A, Polyclonal Antibody
Full Product Name
Pan PDE9A Antibody BIOTIN-Conjugated
Product Gene Name
anti-PDE9A antibody
Product Synonym Names
FLJ90181; HSPDE9A2; PDE 9A; Pde9a; Phosphodiesterase 9A; phosphodiesterase PDE9A21 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
BIOTIN-Conjugated
Concentration
0.55 ug/ul in antibody stabilization buffer (lot specific)
Specificity
This antibody does not cross-react with PDE9B protein or any other PDE family members.
Preparation and Storage
-20 degree C for long term storage
Matching Pairs
Antibody: PDE9A (MBS543576)
Positive Control: PDE9A (MBS543103)
Antibody/Peptide Pairs
PDE9A peptide (MBS544235) is used for blocking the activity of PDE9A antibody (MBS543576)
Molecular Weight
56,554 Da
OMIM
602973
3D Structure
ModBase 3D Structure for O76083
Immunogen
Synthetic cyclic peptide common to all PDE9A variants
Expression
Expressed in all tissues examined (testis, brain, small intestine, skeletal muscle, heart, lung, thymus, spleen, placenta, kidney, liver, pancreas, ovary and prostate) except blood. Highest levels in brain, heart, kidney, spleen, prostate and colon. Isoform PDE9A12 is found in prostate.
Molecular Function
Hydrolase, 3', 5' -cyclic-GMP phosphodiesterase activity
Subcellular Location
Isoform PDE9A1: Cell projection, Cytoplasm, Golgi Apparatus, Endoplasmic Reticulum, Isoform PDE9A2: Cell projection, Cytoplasm, Isoform PDE9A3: Cytoplasm, Endoplasmic Reticulum, Isoform PDE9A17: Cytoplasm, Endoplasmic Reticulum
Applications Tested/Suitable for anti-PDE9A antibody
ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-PDE9A antibody
Confocal Microscopy||1:100
Dot Blot: 1:100
ELISA: 1:100
Immunocytochemistry: 1:100
Immunofluorescence: 1:100
Immunohistochemistry: 1:100
Immunoprecipitation: 1:250
Western Blot: 1:500

Other Notes

Small volumes of anti-PDE9A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PDE9A purchase

MBS543576 is an antibody targeting PDE9A. Also known as Pan PDE9A Antibody BIOTIN-Conjugated. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PDE9A. It may not necessarily be applicable to this product.

NCBI GI #
4505675
NCBI GeneID
5152
NCBI Accession #
NP_002597.1
UniProt Primary Accession #
O76083
UniProt Secondary Accession #
O75490; O75491; O95225; Q53Y40; Q5QD39; Q86SF7; Q86SI6; B2RBI5; B4DFI5; D3DSJ8; D3DSJ9
UniProt Related Accession #
O76083
GenBank Nucleotide #
NM_002606.2
NCBI Official Full Name
high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform a
NCBI Official Synonym Full Names
phosphodiesterase 9A
NCBI Official Symbol
PDE9A
NCBI Official Synonym Symbols
HSPDE9A2
UniProt Protein Name
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Protein Family
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase
UniProt Gene Name
PDE9A
UniProt Entry Name
PDE9A_HUMAN
NCBI Protein Information
high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

NCBI Summary for PDE9A

The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for PDE9A

Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:9624146, PubMed:18757755, PubMed:21483814). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory ().
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Research Articles on PDE9A

1. PDE9A can regulate cGMP signalling independent of the nitric oxide pathway, and its role in stress-induced heart disease suggests potential as a therapeutic target.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PDE9A antibody

 Products by Pathway  Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Nitric Oxide Stimulates Guanylate Cyclase Pathway antibodies  Nitric Oxide Stimulates Guanylate Cyclase Pathway Diagram
 Platelet Homeostasis Pathway antibodies  Platelet Homeostasis Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Regulation Of Androgen Receptor Activity Pathway antibodies  Regulation Of Androgen Receptor Activity Pathway Diagram
 CGMP Effects Pathway antibodies  CGMP Effects Pathway Diagram

Diseases associated with anti-PDE9A antibody

 Disease Name  Pubmed Publications
 Cognition Disorders Antibodies  >5 publications with PDE9A and Cognition Disorders
 Disease Models, Animal Antibodies  >3 publications with PDE9A and Disease Models, Animal
 Hypertrophy Antibodies  >3 publications with PDE9A and Hypertrophy
 Heart Diseases Antibodies  >3 publications with PDE9A and Heart Diseases
 Breast Neoplasms Antibodies  >2 publications with PDE9A and Breast Neoplasms
 Learning Disorders Antibodies  >2 publications with PDE9A and Learning Disorders
 Necrosis Antibodies  >2 publications with PDE9A and Necrosis
 Lung Neoplasms Antibodies  >1 publications with PDE9A and Lung Neoplasms
 Abnormalities, Multiple Antibodies  >1 publications with PDE9A and Abnormalities, Multiple
 Hypertension Antibodies  >1 publications with PDE9A and Hypertension

Organs/Tissues associated with anti-PDE9A antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >19 publications with PDE9A and Brain
 Nerve Antibodies  >3 publications with PDE9A and Nerve
 Spleen Antibodies  >3 publications with PDE9A and Spleen
 Liver Antibodies  >2 publications with PDE9A and Liver
 Eye Antibodies  >2 publications with PDE9A and Eye
 Embryonic Tissue Antibodies  >2 publications with PDE9A and Embryonic Tissue
 Lymph Node Antibodies  >2 publications with PDE9A and Lymph Node
 Lymph Antibodies  >2 publications with PDE9A and Lymph
 Prostate Antibodies  >2 publications with PDE9A and Prostate
 Ovary Antibodies  >1 publications with PDE9A and Ovary
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