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Phospho-PDE3A (PDE3A) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS544178

FITC-Conjugated Phosphorylated cGMP-inhibited 3', 5'-cyclic phosphodiesterase A AntibodyCyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.… More details

$680 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Phospho-PDE3A, Polyclonal Antibody
Full Product Name
Phospho PDE3A Antibody FITC-Conjugated
Product Gene Name
anti-PDE3A antibody
Product Synonym Names
5''-cyclic phosphodiesterase A; cAMP phosphodiesterase myocardial cGMP inhibited; CGI PDE; CGI PDE A; cGMP inhibited 3' 5' cyclic phosphodiesterase A; Cyclic GMP-inhibited phosphodiesterase A; Human cGMP inhibited cAMP phosphodiesterase mRNA; PDE 3A; Phosphodiesterase 3A; Phosphodiesterase 3A cGMP inhibited antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Chicken, Human, Mouse, Rat
Form/Format
FITC-Conjugated
Concentration
1.0-1.25 ug/ul in antibody stabilization buffer (lot specific)
Preparation and Storage
-20 degree C for long term storage
Matching Pairs
Antibody: Phospho-PDE3A (MBS544178)
Positive Control: Phospho-PDE3A (MBS543151)
Antibody/Peptide Pairs
Phospho-PDE3A peptide (MBS544309) is used for blocking the activity of Phospho-PDE3A antibody (MBS544178)
Molecular Weight
124,513 Da
3D Structure
ModBase 3D Structure for Q9Z0X4
Immunogen
Synthetic peptide taken within amino acid region 250-300 on mouse PDE3A protein.
Modification
Phosphorylated
Molecular Function
Hydrolase, 3', 5'-cyclic-AMP phosphodiesterase activity, cAMP binding
Subcellular Location
Membrane; Multipass membrane protein
Applications Tested/Suitable for anti-PDE3A antibody
ELISA (EIA), IMM, Western Blot (WB)
Application Notes for anti-PDE3A antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunoprecipitation: 1:200
Western Blot: 1:500

Other Notes

Small volumes of anti-PDE3A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PDE3A purchase

MBS544178 is an antibody targeting PDE3A. Also known as Phospho PDE3A Antibody FITC-Conjugated. Reactive in Chicken, Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PDE3A. It may not necessarily be applicable to this product.

NCBI GI #
9055304
NCBI GeneID
54611
NCBI Accession #
NP_061249.1
UniProt Primary Accession #
Q9Z0X4
UniProt Related Accession #
Q9Z0X4
GenBank Nucleotide #
NM_018779.1
NCBI Official Full Name
cGMP-inhibited 3',5'-cyclic phosphodiesterase A
NCBI Official Synonym Full Names
phosphodiesterase 3A, cGMP inhibited
NCBI Official Symbol
Pde3a
NCBI Official Synonym Symbols
C87899; A930022O17Rik
UniProt Protein Name
cGMP-inhibited 3',5'-cyclic phosphodiesterase A
UniProt Synonym Protein Names
Cyclic GMP-inhibited phosphodiesterase A; CGI-PDE A
Protein Family
cGMP-inhibited 3',5'-cyclic phosphodiesterase
UniProt Gene Name
Pde3a
UniProt Synonym Gene Names
CGI-PDE A
UniProt Entry Name
PDE3A_MOUSE
NCBI Protein Information
cGMP-inhibited 3',5'-cyclic phosphodiesterase A

UniProt Comments for PDE3A

PDE3A: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Inhibited by cGMP. Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily.

Protein type: Nucleotide Metabolism - purine; EC 3.1.4.17; Phosphodiesterase; Membrane protein, multi-pass; Membrane protein, integral

Cellular Component: cytosol; integral to membrane; membrane

Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; cAMP binding; cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; hydrolase activity; metal ion binding; phosphoric diester hydrolase activity

Biological Process: cAMP catabolic process; cAMP-mediated signaling; cGMP-mediated signaling; negative regulation of apoptosis; negative regulation of vascular permeability; oocyte maturation; positive regulation of vascular permeability; regulation of meiosis; response to drug; signal transduction
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Research Articles on PDE3A

1. These together indicate that PDE3A1 negatively regulates beta-AR signaling and protects against I/R injury by inhibiting cardiomyocyte apoptosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PDE3A antibody

 Reference Product  PubMed Publications
 Akt1 antibody  >1 publications with PDE3A and Akt1

Pathways associated with anti-PDE3A antibody

 Products by Pathway  Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Nitric Oxide Stimulates Guanylate Cyclase Pathway antibodies  Nitric Oxide Stimulates Guanylate Cyclase Pathway Diagram
 Platelet Homeostasis Pathway antibodies  Platelet Homeostasis Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram

Diseases associated with anti-PDE3A antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >31 publications with PDE3A and Cardiovascular Diseases
 Thrombosis Antibodies  >17 publications with PDE3A and Thrombosis
 Vascular Diseases Antibodies  >16 publications with PDE3A and Vascular Diseases
 Heart Failure Antibodies  >16 publications with PDE3A and Heart Failure
 Hypertension Antibodies  >10 publications with PDE3A and Hypertension
 Infertility, Female Antibodies  >8 publications with PDE3A and Infertility, Female
 Lung Diseases Antibodies  >6 publications with PDE3A and Lung Diseases
 Necrosis Antibodies  >5 publications with PDE3A and Necrosis
 Fibrosis Antibodies  >5 publications with PDE3A and Fibrosis
 Hypertrophy Antibodies  >3 publications with PDE3A and Hypertrophy

Organs/Tissues associated with anti-PDE3A antibody

 Organ/Tissue Name  Pubmed Publications
 Artery Antibodies  >22 publications with PDE3A and Artery
 Ovary Antibodies  >15 publications with PDE3A and Ovary
 Brain Antibodies  >12 publications with PDE3A and Brain
 Kidney Antibodies  >8 publications with PDE3A and Kidney
 Pancreas Antibodies  >6 publications with PDE3A and Pancreas
 Embryonic Tissue Antibodies  >5 publications with PDE3A and Embryonic Tissue
 Intestine Antibodies  >4 publications with PDE3A and Intestine
 Lymph Node Antibodies  >1 publications with PDE3A and Lymph Node
 Eye Antibodies  >1 publications with PDE3A and Eye
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