Phospho-PRP19 (PRP19) Antibody – Rabbit Polyclonal

PRPF19: Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Belongs to the WD repeat PRP19 family.

Protein type: EC 6.3.2.19; Ubiquitin conjugating system; Spliceosome; RNA splicing; EC 6.3.2.-; Ligase; Ubiquitin ligase

Cellular Component: cytoplasm; DNA replication factor A complex; lipid particle; membrane; nuclear speck; nucleoplasm; nucleus; spindle; spliceosome

Molecular Function: identical protein binding; ligase activity; protein binding

Biological Process: assembly of spliceosomal tri-snRNP; double-strand break repair via nonhomologous end joining; inner cell mass cell proliferation; lipid biosynthetic process; negative regulation of neuron differentiation; nuclear mRNA splicing, via spliceosome; positive regulation of astrocyte differentiation; positive regulation of neuron differentiation; positive regulation of nuclear mRNA splicing, via spliceosome; proteasomal protein catabolic process; protein polyubiquitination; spliceosome assembly