PREX1 Antibody – Rabbit Polyclonal

The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008]

PREX1: Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. Interacts preferentially with RAC2. Interacts with RAC1. Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Rac/Rho

Chromosomal Location of Human Ortholog: 20q13.13

Cellular Component: cytoplasm; cytosol; dendritic shaft; growth cone; intracellular membrane-bound organelle; perinuclear region of cytoplasm; plasma membrane

Molecular Function: enzyme binding; GTPase activator activity; phospholipid binding; protein binding; Rho guanyl-nucleotide exchange factor activity

Biological Process: actin filament polymerization; G-protein coupled receptor protein signaling pathway; neutrophil activation; neutrophil chemotaxis; positive regulation of GTPase activity; regulation of actin filament polymerization; regulation of dendrite development; regulation of Rho protein signal transduction; superoxide metabolic process; T cell differentiation