Prominin 2 (PROM2) Antibody – Rabbit Polyclonal

This gene encodes a member of the prominin family of pentaspan membrane glycoproteins. The encoded protein localizes to basal epithelial cells and may be involved in the organization of plasma membrane microdomains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

PROM2: a multi-pass membrane protein of the prominin family that binds cholesterol. Localizes to the apical and basolateral membranes of epithelial cells. Present in saliva within small membrane particles. Expressed in kidney, prostate, trachea, esophagus, salivary gland, thyroid gland, mammary gland adrenal gland, placenta, stomach, spinal cord and liver. In submucosal tumor, expressed in spindle-shaped or stellate stromal cells. Expressed in prostate cancer cell lines. Three alternatively spliced human isoforms have been described.

Protein type: Cell surface; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q11.1

Cellular Component: apical plasma membrane; basolateral plasma membrane; cell projection; cell surface; cilium; cytoplasmic vesicle; integral to plasma membrane; lipid raft; microvillus; microvillus membrane

Molecular Function: cholesterol binding

Biological Process: negative regulation of pinocytosis; positive regulation of cell projection organization and biogenesis; positive regulation of protein amino acid phosphorylation; regulation of GTPase activity