Quiescin Q6 (QSOX1) Antibody – Rabbit Polyclonal

This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

quiescin Q6: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. In fibroblasts, it may have tumor- suppressing capabilities being involved in growth regulation. Belongs to the quiescin-sulfhydryl oxidase (QSOX) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; EC 1.8.3.2; Oxidoreductase

Chromosomal Location of Human Ortholog: 1q24

Cellular Component: extracellular region; extracellular space; Golgi apparatus; integral to Golgi membrane; intercellular bridge; intracellular membrane-bound organelle

Molecular Function: flavin-linked sulfhydryl oxidase activity; protein disulfide isomerase activity

Biological Process: cell redox homeostasis; negative regulation of macroautophagy; platelet degranulation; protein folding