• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

RIC8A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS544702

BIOTIN-Conjugated Synembryn-A isoform 1 AntibodyGuanine nucleotide exchange factor (GEF) which can activate some G-alpha proteins.  Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. More details

$610 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
RIC8A, Polyclonal Antibody
Full Product Name
RIC8A Antibody BIOTIN-Conjugated
Product Gene Name
anti-RIC8A antibody
Product Synonym Names
Protein Ric-8A; resistance to inhibitors of cholinesterase 8 homolog A (C. elegans); RIC8; Synembryn-A antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
BIOTIN-Conjugated
Concentration
0.60-0.75 ug/ul in antibody stabilization buffer (lot specific)
Preparation and Storage
-20 degree C for long term storage
Matching Pairs
Antibody: RIC8A (MBS544702)
Positive Control: RIC8A (MBS543194)
Antibody/Peptide Pairs
RIC8A peptide (MBS544370) is used for blocking the activity of RIC8A antibody (MBS544702)
Molecular Weight
59,612 Da
OMIM
609146
3D Structure
ModBase 3D Structure for Q9NPQ8
Immunogen
Synthetic peptide taken within amino acids 500-535 on RIC8A protein
Molecular Function
guanyl-nucleotide exchange factor activity, Guanine-nucleotide releasing factor
Subcellular Location
Interacts with GDP-bound G alpha proteins GNAI1, GNAO1 and GNAQ, and with GNA13 with lower affinity.  Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.
Applications Tested/Suitable for anti-RIC8A antibody
ELISA (EIA), IMM, Western Blot (WB)
Application Notes for anti-RIC8A antibody
Immunoprecipitation: 1:200
Western Blot: 1:250

Other Notes

Small volumes of anti-RIC8A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RIC8A purchase

MBS544702 is an antibody targeting RIC8A. Also known as RIC8A Antibody BIOTIN-Conjugated. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RIC8A. It may not necessarily be applicable to this product.

NCBI GI #
27883866
NCBI GeneID
60626
NCBI Accession #
NP_068751.4
UniProt Primary Accession #
Q9NPQ8
UniProt Secondary Accession #
Q0P508; Q2T9J1; Q7Z352; Q96EZ1; Q96SZ2; Q9H064; Q9H5H3; Q9H9E7
UniProt Related Accession #
Q9NPQ8
GenBank Nucleotide #
NM_021932.5
NCBI Official Full Name
synembryn-A isoform 1
NCBI Official Synonym Full Names
RIC8 guanine nucleotide exchange factor A
NCBI Official Symbol
RIC8A
NCBI Official Synonym Symbols
RIC8
UniProt Protein Name
Synembryn-A
UniProt Synonym Protein Names
Protein Ric-8A
Protein Family
Synembryn
UniProt Gene Name
RIC8A
UniProt Entry Name
RIC8A_HUMAN
NCBI Protein Information
synembryn-A

UniProt Comments for RIC8A

RIC8A: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation. Belongs to the synembryn family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs, misc.; GEFs

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: cytoplasm; plasma membrane

Molecular Function: G-protein alpha-subunit binding; GTPase activator activity; guanyl-nucleotide exchange factor activity; protein binding

Biological Process: cell migration involved in gastrulation; G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; in utero embryonic development; positive regulation of GTPase activity; vasculature development; visual learning
Show more

Research Articles on RIC8A

1. Human NCS-1 and Ric8a reproduce the binding and maintain the structural requirements at these key positions. Drosophila Ric8a and Galphas regulate synapse number and neurotransmitter release, and both are functionally linked to Frq2.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RIC8A antibody

 Reference Product  PubMed Publications
 GNAI1 antibody  >1 publications with RIC8A and GNAI1

Diseases associated with anti-RIC8A antibody

 Disease Name  Pubmed Publications
 Neurologic Manifestations Antibodies  >1 publications with RIC8A and Neurologic Manifestations

Organs/Tissues associated with anti-RIC8A antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with RIC8A and Brain
 Kidney Antibodies  >2 publications with RIC8A and Kidney
 Heart Antibodies  >1 publications with RIC8A and Heart
 Ovary Antibodies  >1 publications with RIC8A and Ovary
 Muscle Antibodies  >1 publications with RIC8A and Muscle
 Embryonic Tissue Antibodies  >1 publications with RIC8A and Embryonic Tissue
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000