ROBO3 Antibody – Rabbit Polyclonal

HOMER1: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Interacts with IFT57. Interacts with OPHN1. Isoform 1 encodes a coiled-coil structure that mediates homo- and heteromultimerization. Belongs to the Homer family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Contractile; Cell development/differentiation; Cell adhesion; Adaptor/scaffold

Cellular Component: apical part of cell; axon; cell junction; cell soma; costamere; cytoplasm; dendrite; dendritic shaft; excitatory synapse; membrane; neuron projection; plasma membrane; postsynaptic density; postsynaptic membrane; synapse; Z disc

Molecular Function: identical protein binding; metabotropic glutatmate receptor binding; protein binding; protein complex scaffold; protein heterodimerization activity; receptor binding; type 5 metabotropic glutamate receptor binding

Biological Process: behavioral response to cocaine; chemical homeostasis within a tissue; circadian rhythm; metabotropic glutamate receptor signaling pathway; positive regulation of calcium ion transport; response to calcium ion; response to cocaine; response to nicotine; skeletal muscle contraction; skeletal muscle fiber development