RIP140 Antibody – Rabbit Polyclonal

RIP140: Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Interacts with RARA and RXRB homodimers and RARA/RXRB heterodimers in the presence of ligand. Interacts with HDAC1 and HDAC3 via its N-terminal domain. Interacts with NR2C1 (sumoylated form and via the ligand-binding domain); the interaction results in promoting the repressor activity of NR2C1. Interacts with CTBP1, CTBP2, ESR1, HDAC1, HDAC2, HDAC5, HDAC6, NR2C2, NR3C1, NR3C2, YWHAH, JUN and FOS. Found in a complex with both NR3C1 and YWHAH. Interacts with ZNF366.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Cellular Component: cell junction; histone deacetylase complex; nuclear chromatin; nuclear speck; nucleolus; nucleoplasm; nucleus

Molecular Function: estrogen receptor binding; glucocorticoid receptor binding; histone deacetylase binding; nuclear hormone receptor binding; protein binding; receptor binding; retinoic acid receptor binding; retinoid X receptor binding; transcription coactivator activity; transcription cofactor activity; transcription corepressor activity

Biological Process: circadian regulation of gene expression; negative regulation of transcription from RNA polymerase II promoter; ovarian follicle rupture; ovulation; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; rhythmic process; sequestering of lipid; transcription, DNA-dependent