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RIPK5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS544733

Dual serine/threonine and tyrosine protein kinase AntibodyActs as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death. More details

$610 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
RIPK5, Polyclonal Antibody
Full Product Name
RIPK5 Antibody
Product Gene Name
anti-RIPK5 antibody
Product Synonym Names
DSTYK; Dual serine/threonine and tyrosine protein kinase; Dusty PK; Dusty protein kinase; HDCMD38P; KIAA0472; Receptor interacting protein kinase 5; Receptor interacting serine/threonine protein kinase 5; RIP homologous kinase; RIPK5; SgK496; Sugen kinase 496 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Bovine, Human, Monkey, Mouse, Rat
Form/Format
FITC-Conjugated immunoglobulins
Preparation and Storage
Store at -20°C for long term storage.
Matching Pairs
Antibody: RIPK5 (MBS544733)
Positive Control: RIPK5 (MBS543202)
Antibody/Peptide Pairs
RIPK5 peptide (MBS544382) is used for blocking the activity of RIPK5 antibody (MBS544733)
OMIM
610805
3D Structure
ModBase 3D Structure for Q6XUX3
Immunogen
Synthetic peptide taken within amino acid region 200-250 on human Dual serine/threonine and tyrosine protein kinase protein (RIPK5).
Immunoglobulins & Concentration
0.75mg/ml IgG in antibody stabilization buffer
Applications Tested/Suitable for anti-RIPK5 antibody
ELISA (EIA), IMM, Western Blot (WB)
Application Notes for anti-RIPK5 antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunoprecipitation: 1:150
Western Blot: 1:500

Other Notes

Small volumes of anti-RIPK5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RIPK5 purchase

MBS544733 is an antibody targeting RIPK5. Also known as RIPK5 Antibody. Reactive in Bovine, Human, Monkey, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RIPK5. It may not necessarily be applicable to this product.

NCBI GI #
296434486
NCBI GeneID
25778
NCBI Accession #
Q6XUX3.2
UniProt Primary Accession #
Q6XUX3
UniProt Secondary Accession #
O75060; Q17R94; Q5RKT0; Q6IN87; Q6P997; Q86Y03; Q9P1S5; B7ZL64
UniProt Related Accession #
Q6XUX3
NCBI Official Full Name
Dual serine/threonine and tyrosine protein kinase
NCBI Official Synonym Full Names
dual serine/threonine and tyrosine protein kinase
NCBI Official Symbol
DSTYK
NCBI Official Synonym Symbols
RIP5; RIPK5; CAKUT1; DustyPK; HDCMD38P
UniProt Protein Name
Dual serine/threonine and tyrosine protein kinase
UniProt Synonym Protein Names
Dusty protein kinase; Dusty PK; RIP-homologous kinase; Receptor-interacting serine/threonine-protein kinase 5; Sugen kinase 496; SgK496
UniProt Gene Name
DSTYK
UniProt Synonym Gene Names
KIAA0472; RIP5; RIPK5; SGK496; Dusty PK; SgK496
UniProt Entry Name
DUSTY_HUMAN
NCBI Protein Information
dual serine/threonine and tyrosine protein kinase

NCBI Summary for RIPK5

This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. It is thought to function as a regulator of cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

UniProt Comments for RIPK5

DSTYK: a serine/threonine protein kinase of the 'Other-Unique' family, most closely related to kinases of the TKL family including IRAK and RIPK. Overexpression induces apoptotic cell death. The caspase inhibitor crmA apparently blocks DNA fragmentation but not apoptosis, suggesting that SgK496 may induce both caspase-dependent apoptosis and caspase-independent cell death. Four alternatively spliced isoforms have been described.

Protein type: Protein kinase, Other; EC 2.7.12.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Motility/polarity/chemotaxis; Other group; Other-Unique family

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: apical plasma membrane; basolateral plasma membrane; cell junction; cytoplasm; cytosol

Molecular Function: ATP binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein-tyrosine kinase activity

Biological Process: peptidyl-tyrosine phosphorylation; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of kinase activity

Disease: Congenital Anomalies Of Kidney And Urinary Tract, Susceptibility To
Show more

Research Articles on RIPK5

1. We detected independent DSTYK mutations in 2.3% of patients with congenital abnormalities of the kidney or urinary tract, a finding that suggests that DSTYK is a major determinant of human urinary tract development, downstream of FGF signaling.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-RIPK5 antibody

 Disease Name  Pubmed Publications
 Urogenital Abnormalities Antibodies  >2 publications with RIPK5 and Urogenital Abnormalities
 Learning Disorders Antibodies  >1 publications with RIPK5 and Learning Disorders
 Memory Disorders Antibodies  >1 publications with RIPK5 and Memory Disorders

Organs/Tissues associated with anti-RIPK5 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with RIPK5 and Brain
 Blood Antibodies  >1 publications with RIPK5 and Blood
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