Rabbit Anti-EDG8 Polyclonal Antibody – Cat# MBS544764

EDG8 Antibody – Rabbit Polyclonal

Name: EDG8 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS544764
Price: 480 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS544764

Affinity Purified Sphingosine 1-phosphate receptor 5 AntibodyReceptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both… More details

$480 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

EDG8, Polyclonal Antibody

Full Product Name

EDG8 Antibody

Product Gene Name

anti-EDG8 antibody

Product Synonym Names

EDG 8; Endothelial differentiation G protein coupled receptor 8; Endothelial differentiation sphingolipid G protein coupled receptor 8; S1P receptor 5; S1P receptor Edg 8; Sphingosine 1 Phosphate Receptor 5; Sphingosine 1-phosphate receptor Edg-8; SPPR2 antibody

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

Affinity Purified

Concentration

0.52-0.63 ug/ul in antibody stabilization buffer (lot specific)

Specificity

Does not cross eact to other Spingosine 1-phosphate receptor subtypes. Labels a strong band of EDG8 of 48-50 kDa. Also labels a 54 kDa band, the identity of this is not known but may represent phosphorylated EDG8.

Preparation and Storage

-20 degree C for long term storage

Matching Pairs

Antibody: EDG8 (MBS544764)
Positive Control: EDG8 (MBS543215)

Antibody/Peptide Pairs

EDG8 peptide (MBS544409) is used for blocking the activity of EDG8 antibody (MBS544764)

Molecular Weight

42,369 Da

3D Structure

ModBase 3D Structure for Q9JKM5

Immunogen

Synthetic peptide taken within amino acid region 380-400 of rat S1P5R/EDG8 protein.

Expression

Found almost exclusively in brain and skin. Ubiquitously detected in different brain regions with very prominent expression in lower brain regions such as the midbrain, pons, medulla, and spinal cord. Expressed predominantly within white matter tracts of

Molecular Function

G-protein coupled receptor, Receptor, Transducer

Subcellular Location

Cell membrane; Multi-pass membrane protein

Product Categories/Family for anti-EDG8 antibody

Primary Antibodies; Signal Transduction; G-Protein Coupled Receptors; EDG8 Antibody

Applications Tested/Suitable for anti-EDG8 antibody

ELISA (EIA), Western Blot (WB)

Application Notes for anti-EDG8 antibody

Dot Blot: 1:10,000
ELISA: 1:10,000
Western Blot: 1:500

Other Notes

Small volumes of anti-EDG8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EDG8 purchase

MBS544764 is an antibody targeting EDG8. Also known as EDG8 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for EDG8. It may not necessarily be applicable to this product.

NCBI GI #

62510532

NCBI GeneID

60399

NCBI Accession #

Q9JKM5.1

UniProt Primary Accession #

Q9JKM5

UniProt Secondary Accession #

Q9QY79

UniProt Related Accession #

Q9JKM5

NCBI Official Full Name

Sphingosine 1-phosphate receptor 5

NCBI Official Synonym Full Names

sphingosine-1-phosphate receptor 5

NCBI Official Symbol

S1pr5

NCBI Official Synonym Symbols

Edg8; Edg-8

UniProt Protein Name

Sphingosine 1-phosphate receptor 5

UniProt Synonym Protein Names

Endothelial differentiation G-protein-coupled receptor 8; Nerve growth factor-regulated G-protein-coupled receptor 1; NRG-1; Sphingosine 1-phosphate receptor Edg-8; S1P receptor Edg-8

UniProt Gene Name

S1pr5

UniProt Synonym Gene Names

Edg8; Nrg1; S1P receptor 5; S1P5; NRG-1; S1P receptor Edg-8

UniProt Entry Name

S1PR5_RAT

NCBI Protein Information

sphingosine 1-phosphate receptor 5

NCBI Summary for EDG8

G protein-coupled receptor for the lysolipid phosphoric acid mediator sphingosine 1-phosphate [RGD, Feb 2006]

UniProt Comments for EDG8

EDG8: Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins. May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Cellular Component: integral to membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity

Biological Process: regulation of neuron differentiation

Research Articles on EDG8

1. The LOC290876-encoded gene product (EDG-8) has distinct roles in the nucleus during the processes of spermatocyte maturation and spermatid production in meiosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-EDG8 antibody

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Lysosphingolipid And LPA Receptors Pathway antibodies	Lysosphingolipid And LPA Receptors Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signal Transduction Of S1P Pathway antibodies	Signal Transduction Of S1P Pathway Diagram
Signaling By GPCR Pathway antibodies	Signaling By GPCR Pathway Diagram

Diseases associated with anti-EDG8 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>5 publications with EDG8 and Inflammation
Vascular Diseases Antibodies	>3 publications with EDG8 and Vascular Diseases
Immune System Diseases Antibodies	>3 publications with EDG8 and Immune System Diseases
Lung Diseases Antibodies	>3 publications with EDG8 and Lung Diseases
Kidney Diseases Antibodies	>1 publications with EDG8 and Kidney Diseases
Insulin Resistance Antibodies	>1 publications with EDG8 and Insulin Resistance
Memory Disorders Antibodies	>1 publications with EDG8 and Memory Disorders
Glucose Intolerance Antibodies	>1 publications with EDG8 and Glucose Intolerance
Liver Neoplasms Antibodies	>1 publications with EDG8 and Liver Neoplasms
Lung Neoplasms Antibodies	>1 publications with EDG8 and Lung Neoplasms

Organs/Tissues associated with anti-EDG8 antibody

Organ/Tissue Name	Pubmed Publications
Spleen Antibodies	>3 publications with EDG8 and Spleen
Brain Antibodies	>3 publications with EDG8 and Brain
Adrenal Gland Antibodies	>1 publications with EDG8 and Adrenal Gland