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SESN1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS544837

FITC-Conjugated Sestrin-1 AntibodyInvolved in the reduction of peroxiredoxins. May also be regulator of cellular growth. More details

$610 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SESN1, Polyclonal Antibody
Full Product Name
SESN1 Antibody FITC-Conjugated
Product Gene Name
Product Synonym Names
1110002G11Rik; AU044290; p53 activated gene 26; p53 regulated PA26 nuclear protein; PA26; RP11-787I22.1; sesn1; SEST1; Sestrin-1 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
FITC-Conjugated
Concentration
0.55 ug/ul in antibody stabilization buffer (lot specific)
Preparation and Storage
-20 degree C for long term storage
Matching Pairs
Antibody: SESN1 (MBS544837)
Positive Control: SESN1 (MBS543239)
Antibody/Peptide Pairs
SESN1 peptide (MBS544450) is used for blocking the activity of SESN1 antibody (MBS544837)
Molecular Weight
49,624 Da
OMIM
606103
3D Structure
ModBase 3D Structure for Q9Y6P5
Immunogen
Synthetic peptide taken within amino acid region 1-50 on human SESN1 protein.
Expression
Widely Expressed
Molecular Function
Cell cycle arrest; Cellular response to DNA damage stimulus; Gene expression; Regulation of protein kinase B signaling; Transcription initation from RNA polymerase II promoter; Regulation of response to reactive oxygen species; Negative regulation of cell
Structure
Belongs to the Sestrin family.
Subcellular Location
Nucleus
Applications Tested/Suitable for anti-SESN1 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-SESN1 antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Western Blot: 1:500

Other Notes

Small volumes of anti-SESN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SESN1 purchase

MBS544837 is an antibody targeting SESN1. Also known as SESN1 Antibody FITC-Conjugated. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SESN1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Sestrin-1
NCBI Official Synonym Full Names
sestrin 1
NCBI Official Symbol
SESN1
NCBI Official Synonym Symbols
PA26; SEST1
UniProt Protein Name
Sestrin-1
UniProt Synonym Protein Names
p53-regulated protein PA26
Protein Family
UniProt Gene Name
SESN1
UniProt Synonym Gene Names
PA26; SEST1
UniProt Entry Name
SESN1_HUMAN
NCBI Protein Information
sestrin-1

NCBI Summary for SESN1

This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
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UniProt Comments for SESN1

SESN1: Involved in the reduction of peroxiredoxins. May also be regulator of cellular growth. Belongs to the sestrin family. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 6q21

Cellular Component: cytosol; nucleus

Biological Process: cell cycle arrest; negative regulation of cell proliferation; response to DNA damage stimulus
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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