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SOCS3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS544937

Affinity Purified SOCS3, partial AntibodySOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway.… More details

$480 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SOCS3, Polyclonal Antibody
Full Product Name
SOCS3 Antibody Affinity Purified
Product Gene Name
anti-SOCS3 antibody
Product Synonym Names
ATOD4; CIS 3; Cish3; Cytokine induced SH2 protein 3; E2a Pbx1 target gene in fibroblasts 10; EF 10; SOCS 3; SSI3; STAT induced STAT inhibitor 3; Suppressor of cytokine signaling 3 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Affinity Purified
Concentration
0.50 ug/ul in antibody stabilization buffer (lot specific)
Preparation and Storage
-20 degree C for long term storage
Matching Pairs
Antibody: SOCS3 (MBS544937)
Positive Control: SOCS3 (MBS543274)
Antibody/Peptide Pairs
SOCS3 peptide (MBS544498) is used for blocking the activity of SOCS3 antibody (MBS544937)
Molecular Weight
24,770 Da
3D Structure
ModBase 3D Structure for Q6FI39
Immunogen
Synthetic peptide taken within amino acid region 175-225 on human SOCS3 protein.
Expression
Widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. Lower levels in thymus.
Molecular Function
Protein modification; protein ubiquitination.
Structure
Interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1 receptor, insulin receptor and JAK2. Binding to JAK2 is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK2 JH1 domain. Binds specific activated tyrosine residues of the leptin, EPO, IL12, GSCF and gp130 receptors. Interaction with CSNK1E stabilizes SOCS3 protein. Component of the probable ECS(SOCS3) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SOCS3. Interacts with CUL5, RNF7, TCEB1 and TCEB2. Interacts with CUL2. Interacts with FGFR3. Interacts with INSR (By similarity). Interacts with BCL10; this interaction may interfere with BCL10-binding with PELI2.
Subcellular Location
Cytoplasm

Product Categories/Family for anti-SOCS3 antibody

Primary Antibodies; Immunology; Innate Immunity; Cytokines; SOCS3 Antibody
Applications Tested/Suitable for anti-SOCS3 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-SOCS3 antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Western Blot: 1:500

Western Blot (WB) of anti-SOCS3 antibody

Rabbit Anti-SOCS3 Polyclonal Antibody – Cat# MBS544937

Other Notes

Small volumes of anti-SOCS3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SOCS3 purchase

MBS544937 is an antibody targeting SOCS3. Also known as SOCS3 Antibody Affinity Purified. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SOCS3. It may not necessarily be applicable to this product.

NCBI GI #
49456349
NCBI GeneID
9021
NCBI Accession #
CAG46495
UniProt Primary Accession #
Q6FI39
UniProt Related Accession #
O14543
NCBI Official Full Name
SOCS3, partial
NCBI Official Synonym Full Names
suppressor of cytokine signaling 3
NCBI Official Symbol
SOCS3
NCBI Official Synonym Symbols
CIS3; SSI3; ATOD4; Cish3; SSI-3; SOCS-3
UniProt Protein Name
SOCS3 protein
UniProt Synonym Protein Names
SOCS3 protein
Protein Family
Suppressor of cytokine signaling
UniProt Gene Name
SOCS3
UniProt Entry Name
Q6FI39_HUMAN
NCBI Protein Information
suppressor of cytokine signaling 3

NCBI Summary for SOCS3

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]
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Research Articles on SOCS3

1. SOCS3 down-expression induces lineage commitment towards erythroid progenitor cell fate by activation of erythroid-specific gene in HSCs

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SOCS3 antibody

 Reference Product  PubMed Publications
 STAT3 antibody  >877 publications with SOCS3 and STAT3
 JAK2 antibody  >219 publications with SOCS3 and JAK2
 JAK1 antibody  >75 publications with SOCS3 and JAK1
 IRS1 antibody  >49 publications with SOCS3 and IRS1
 IL6ST antibody  >38 publications with SOCS3 and IL6ST
 PTPN11 antibody  >25 publications with SOCS3 and PTPN11
 STAT5B antibody  >23 publications with SOCS3 and STAT5B
 JAK3 antibody  >23 publications with SOCS3 and JAK3
 STAT5A antibody  >13 publications with SOCS3 and STAT5A
 INSR antibody  >5 publications with SOCS3 and INSR

Pathways associated with anti-SOCS3 antibody

 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 ECS Complex Pathway antibodies  ECS Complex Pathway Diagram
 ECS Complex Pathway antibodies  ECS Complex Pathway Diagram

Diseases associated with anti-SOCS3 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >524 publications with SOCS3 and Inflammation
 Necrosis Antibodies  >252 publications with SOCS3 and Necrosis
 Disease Models, Animal Antibodies  >170 publications with SOCS3 and Disease Models, Animal
 Liver Diseases Antibodies  >152 publications with SOCS3 and Liver Diseases
 Nervous System Diseases Antibodies  >122 publications with SOCS3 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >103 publications with SOCS3 and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >69 publications with SOCS3 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >50 publications with SOCS3 and Carcinoma, Hepatocellular
 Heart Diseases Antibodies  >47 publications with SOCS3 and Heart Diseases
 Fibrosis Antibodies  >44 publications with SOCS3 and Fibrosis

Organs/Tissues associated with anti-SOCS3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >661 publications with SOCS3 and Blood
 Liver Antibodies  >303 publications with SOCS3 and Liver
 Brain Antibodies  >245 publications with SOCS3 and Brain
 Bone Antibodies  >114 publications with SOCS3 and Bone
 Adipose Tissue Antibodies  >114 publications with SOCS3 and Adipose Tissue
 Lung Antibodies  >110 publications with SOCS3 and Lung
 Vascular Antibodies  >98 publications with SOCS3 and Vascular
 Heart Antibodies  >89 publications with SOCS3 and Heart
 Connective Tissue Antibodies  >82 publications with SOCS3 and Connective Tissue
 Kidney Antibodies  >70 publications with SOCS3 and Kidney
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